Capicua in Human Cancer.
Capicua in Human Cancer.
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DOI:
10.1016/j.trecan.2020.08.010
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发表时间:
2021-01
期刊:
影响因子:
18.4
通讯作者:
Okimoto RA
中科院分区:
文献类型:
--
作者:
Kim JW;Ponce RK;Okimoto RA
Capicua (CIC) is a highly conserved transcriptional repressor that is differentially regulated through MAPK signaling or genetic alteration across human cancer. CIC contributes to tumor progression and metastasis through direct transcriptional control of effector target genes. Recent findings indicate that CIC dysregulation is mechanistically linked and restricted to specific cancer subtypes, yet convergence on key downstream transcriptional nodes are critical for CIC-regulated oncogenesis across these cancers. In this review, we focus on how differential regulation of CIC through functional and genetic mechanisms contributes to subtype-specific cancer phenotypes, and we propose new therapeutic strategies to effectively target CIC-altered cancers.
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影响因子:
5.8
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通讯作者:
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通讯作者:
Rustgi AK
影响因子:
64.8
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通讯作者:
Thomson, Elizabeth