Capicua in Human Cancer.

Capicua in Human Cancer.
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DOI:
10.1016/j.trecan.2020.08.010
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发表时间:
2021-01
期刊:
影响因子:
18.4
通讯作者:
Okimoto RA
Okimoto RA
中科院分区:
医学1区
文献类型:
--
作者:
Kim JW;Ponce RK;Okimoto RA

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Capicua(CIC)是一种高度保守的转录抑制因子,在人类癌症中通过MAPK信号传导或遗传改变进行差异调节。CIC通过效应靶基因的直接转录控制促进肿瘤进展和转移。最近的研究结果表明,CIC失调与特定的癌症亚型有机械联系并仅限于特定的癌症亚型,但关键下游转录节点的收敛对于CIC调节的肿瘤发生在这些癌症中至关重要。在这篇综述中,我们重点关注CIC的差异调节如何通过功能和遗传机制有助于亚型特异性癌症表型,我们提出了新的治疗策略,以有效地针对CIC改变的癌症。
Capicua (CIC) is a highly conserved transcriptional repressor that is differentially regulated through MAPK signaling or genetic alteration across human cancer. CIC contributes to tumor progression and metastasis through direct transcriptional control of effector target genes. Recent findings indicate that CIC dysregulation is mechanistically linked and restricted to specific cancer subtypes, yet convergence on key downstream transcriptional nodes are critical for CIC-regulated oncogenesis across these cancers. In this review, we focus on how differential regulation of CIC through functional and genetic mechanisms contributes to subtype-specific cancer phenotypes, and we propose new therapeutic strategies to effectively target CIC-altered cancers.
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