Alterations of serum lipids in breast cancer: effects of disease activity, treatment, and hormonal factors.
Alterations of serum lipids in breast cancer: effects of disease activity, treatment, and hormonal factors.
复制标题
乳腺癌血清脂质的变化：疾病活动、治疗和激素因素的影响。
DOI：
10.1093/clinchem/37.12.2093
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发表时间：
1991
影响因子：
9.3
通讯作者：
P. Riches
中科院分区：
文献类型：
--
作者：
M. L. Knapp;Said Al;P. Riches
从83例乳腺癌患者中采集空腹静脉血，分析甘油三酯、总胆固醇、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇、肿瘤坏死因子（TNF α）、葡萄糖、肌酐、胰岛素、胰高血糖素、生长激素、皮质醇和促甲状腺激素。IV期疾病患者的甘油三酯浓度显著高于（P <0.05），总胆固醇和HDL胆固醇浓度显著低于（P <0.05）疾病较轻患者或年龄匹配的对照组。此外，骨转移患者的LDL胆固醇浓度显著低于（P <0.05）肝脏或肝脏+骨转移患者或对照组。这些结果不能归因于吸烟习惯、饮酒或治疗。我们观察到血清脂质浓度与TNF α、胰岛素、葡萄糖、肌酐、皮质醇、生长激素或促甲状腺激素浓度之间无相关性。然而，对于II、III和IV期疾病患者，总胆固醇和胰高血糖素之间以及LDL胆固醇和胰高血糖素之间存在显著（P <0.05）负相关性，表明胰高血糖素可能通过尚未确定的机制降低LDL胆固醇浓度。
Fasting venous blood collected from 83 patients with breast cancer was analyzed for triglycerides; total, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol; tumor necrosis factor (TNF alpha); glucose; creatinine; insulin; glucagon; growth hormone; cortisol; and thyrotropin. Patients with stage IV disease had significantly higher (P less than 0.05) triglyceride concentrations and significantly lower (P less than 0.05) concentrations of total and HDL cholesterol than did patients with less advanced disease or age-matched controls. Furthermore, LDL cholesterol concentrations in patients with boney metastases were significantly lower (P less than 0.05) than concentrations in patients with liver or liver plus boney metastases or in controls. These results could not be attributed to smoking habits, alcohol consumption, or treatment. We observed no correlations between serum concentrations of lipid and concentrations of TNF alpha, insulin, glucose, creatinine, cortisol, growth hormone, or thyrotropin. However, there was a significant (P less than 0.05) negative correlation between total cholesterol and glucagon and between LDL cholesterol and glucagon for patients with stage II, III, and IV disease, suggesting that glucagon may reduce LDL cholesterol concentrations by an as-yet-unidentified mechanism.