Impact of preventing exacerbations on deterioration of health status in COPD
Impact of preventing exacerbations on deterioration of health status in COPD
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DOI：
10.1183/09031936.04.00121404
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发表时间：
2004-05-01
影响因子：
24.3
通讯作者：
Jones, PW
中科院分区：
文献类型：
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作者：
Spencer, S;Calverley, PMA;Jones, PW
慢性阻塞性肺疾病（COPD）的恶化与健康状况恶化有关。欧洲阻塞性肺疾病吸入类固醇（ISOLDE）研究表明，与安慰剂相比，丙酸氟替卡松（FP）治疗可减少急性发作频率和健康状况恶化率。本研究分析了这些数据，以检验FP对健康状况的影响是否可归因于其对病情恶化的影响。对613例中重度COPD患者进行最长3年的随访，获得了圣乔治呼吸问卷（SGRQ）总分的恶化率。加重率是倾斜的，不能归一化，因此，患者被分为三个加重组：无加重、不频繁加重（每年1.65次加重（-1））。无加重91例，不常见加重285例，频繁加重235例。频繁的恶化与较差的基线SGRQ评分独立相关(p
Exacerbations of chronic obstuctive pulmonary disease (COPD) are associated with worse health status. The Inhaled Steroids in Obstructive Lung Disease in Europe (ISOLDE) study showed that treatment with fluticasone propionate (FP) reduced exacerbation frequency and the rate of deterioration in health status as compared with placebo. The present study analysed these data to test whether the effect of FP on health status was attributable to its effect on exacerbations.Rates of deterioration in St George's Respiratory Questionnaire (SGRQ) total score were obtained for 613 patients with moderate to severe COPD followed for a maximum of 3 yrs. Exacerbation rates were skewed and could not be normalised, therefore, patients were stratified into three exacerbation groups: none, infrequent (1.65 exacerbations yr(-1)).There were 91 patients with no exacerbations, 285 with infrequent exacerbations and 235 with frequent exacerbations. Frequent exacerbations were independently associated with a worse baseline SGRQ score (p