Low Cerebral Glucose Metabolism: A Potential Predictor for the Severity of Vascular Parkinsonism and Parkinson's Disease.
Low Cerebral Glucose Metabolism: A Potential Predictor for the Severity of Vascular Parkinsonism and Parkinson's Disease.
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DOI：
10.14336/ad.2015.0204
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发表时间：
2015-12
影响因子：
7.4
通讯作者：
Yunqi Xu;Xiaobo Wei;Xu Liu;J. Liao;Jia-ping Lin;Cansheng Zhu;X. Meng;Dong-Xiao Xie;D. Chao;Albert J. Fenoy;Muhua Cheng;B. Tang;Zhuohua Zhang;Ying Xia;Qing Wang
中科院分区：
文献类型：
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作者：
Yunqi Xu;Xiaobo Wei;Xu Liu;J. Liao;Jia-ping Lin;Cansheng Zhu;X. Meng;Dong-Xiao Xie;D. Chao;Albert J. Fenoy;Muhua Cheng;B. Tang;Zhuohua Zhang;Ying Xia;Qing Wang
本研究探讨了脑葡萄糖代谢率（CMRGlc）与血管性帕金森病（VP）和帕金森病（PD）严重程度之间的关系。进行横断面研究以比较正常受试者与VP和PD患者中的CMRGlc。对12例正常人、22例VP和11例PD患者进行了H&Y和MMSE评估，并进行了18F-FDG测量。Pearson相关性用于确定VP/PD严重程度与CMRGlc之间的潜在相关性。与正常人相比，在VP和PD患者中检测到额叶和尾壳核的CMRGlc显著降低。与PD患者相比，VP患者在尾壳核和额叶中显示轻微的CMRGlc降低。额叶和尾壳核中CMRGlc的这些降低与VP患者的H&Y、HMRS II、HMRS III、MMSE、心血管和注意力/记忆分数显著相关。同样，在PD患者中观察到显著相关性。这是第一项发现脑葡萄糖代谢低下与VP和PD严重程度相关的强有力证据的临床研究。我们的研究结果表明，额叶和尾壳核葡萄糖代谢的这些变化可能是VP和PD的病理生理机制的基础。随着寻找影像学生物标志物或疾病预测因子的竞争加剧，更好地了解脑葡萄糖代谢的作用可能会使我们深入了解VP和PD的发病机制。
This study explored the association between cerebral metabolic rates of glucose (CMRGlc) and the severity of Vascular Parkinsonism (VP) and Parkinson's disease (PD). A cross-sectional study was performed to compare CMRGlc in normal subjects vs. VP and PD patients. Twelve normal subjects, 22 VP, and 11 PD patients were evaluated with the H&Y and MMSE, and underwent 18F-FDG measurements. Pearson's correlations were used to identify potential associations between the severity of VP/PD and CMRGlc. A pronounced reduction of CMRGlc in the frontal lobe and caudate putamen was detected in patients with VP and PD when compared with normal subjects. The VP patients displayed a slight CMRGlc decrease in the caudate putamen and frontal lobe in comparison with PD patients. These decreases in CMRGlc in the frontal lobe and caudate putamen were significantly correlated with the VP patients' H&Y, UPDRS II, UPDRS III, MMSE, cardiovascular, and attention/memory scores. Similarly, significant correlations were observed in patients with PD. This is the first clinical study finding strong evidence for an association between low cerebral glucose metabolism and the severity of VP and PD. Our findings suggest that these changes in glucose metabolism in the frontal lobe and caudate putamen may underlie the pathophysiological mechanisms of VP and PD. As the scramble to find imaging biomarkers or predictors of the disease intensifies, a better understanding of the roles of cerebral glucose metabolism may give us insight into the pathogenesis of VP and PD.