Baroreflex function in lifetime-captopril-treated spontaneously hypertensive rats.
Baroreflex function in lifetime-captopril-treated spontaneously hypertensive rats.
复制标题
终生卡托普利治疗的自发性高血压大鼠的压力感受反射功能。
DOI：
10.1161/01.hyp.13.1.63
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Berecek,KH
中科院分区：
文献类型：
--
作者：
Cheng,SW;Swords,BH;Kirk,KA;Berecek,KH
在19-21周龄自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）中，测定了终身口服卡托普利治疗对压力反射控制心率和腰交感神经活动的影响。分别通过平均动脉压（MAP）（mmHg）变化与脉搏间期（msec/beat）变化以及MAP变化与神经活动变化百分比之间关系的斜率来确定压力反射控制心率和腰交感神经活动的敏感性。未经治疗的SHR的MAP显著高于WKY（157 +/- 3 vs. 115 +/- 3 mm Hg，p <0.001），并表现出对心率的压力反射控制降低。终生服用卡托普利可预防SHR（MAP = 110 +/- 5 mm Hg）高血压的发展，并增加压力感受性反射功能的敏感性。当苯肾上腺素或硝普钠升高或降低MAP时，卡托普利治疗的SHR和对照SHR的压力反射控制心率的增益分别为2.38 +/- 0.49 vs. 1.10 +/- 0.33 msec/mm Hg（p <0.05）和0.74 +/- 0.20 vs. 0.54 +/- 0.09（NS）msec/mm Hg。当MAP升高或降低时，卡托普利治疗的SHR的腰交感神经活动的压力反射控制的敏感性高于对照SHR（分别为-1.03 +/- 0.26 vs. -0.38 +/- 0.11，p小于0.05; -0.84 +/- 0.2 vs. -0.04 +/- 0.58（NS）mm Hg-1）。（250字处删节）
The effects of lifetime oral captopril treatment on baroreflex control of heart rate and lumbar sympathetic nerve activity were measured in 19-21-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). The sensitivity of baroreflex control of heart rate and lumbar sympathetic nerve activity were determined by the slopes of the relation between the change in mean arterial pressure (MAP) (mm Hg) versus the change in pulse interval (msec/beat) and the change in MAP versus the percent change in nerve activity, respectively. Untreated SHR had significantly higher MAP than WKY (157 +/- 3 vs. 115 +/- 3 mm Hg, p less than 0.001) and exhibited a decreased baroreflex control of heart rate. Lifetime treatment with captopril prevented the development of hypertension in SHR (MAP = 110 +/- 5 mm Hg) and increased the sensitivity of baroreflex function. The gains of the baroreflex control of heart rate for captopril-treated SHR and control SHR when MAP was raised or lowered by phenylephrine or nitroprusside were 2.38 +/- 0.49 vs. 1.10 +/- 0.33 msec/mm Hg (p less than 0.05) and 0.74 +/- 0.20 vs. 0.54 +/- 0.09 (NS) msec/mm Hg, respectively. The sensitivity of the baroreflex control of lumbar sympathetic nerve activity was greater in captopril-treated SHR than in control SHR when MAP was increased or decreased (-1.03 +/- 0.26 vs. -0.38 +/- 0.11, p less than 0.05; -0.84 +/- 0.2 vs. -0.04 +/- 0.58 (NS) mm Hg-1, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)