Evidence that IFN-alph/beta induces two antiviral states active against different viruses.
Evidence that IFN-alph/beta induces two antiviral states active against different viruses.
复制标题
有证据表明 IFN-α/β 诱导两种针对不同病毒的抗病毒状态。
DOI：
10.1099/0022-1317-66-5-1153
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
FleischmannJr,WR
中科院分区：
文献类型：
--
作者：
Rose,JM;Crowley,CK;FleischmannJr,WR
IFN-α/βhas been suggested to require only one round of mRNA and protein synthesis to induce an antiviral state. We have examined the mechanism of induction of the antiviral states shown against three types of viruses: mengovirus (plus strand, sense RNA), vesicular stomatitis virus (VSV, minus strand RNA), and vaccinia virus (DNA). Mouse L cells were treated with IFN-α/βand cycloheximide and then with actinomycin D on a schedule which allowed only one round of mRNA and protein synthesis. The cells were challenged with virus under single cycle growth conditions to determine the amount of antiviral activity against the particular challenge virus employed. These studies confirmed that most of the antiviral effect directed against VSV is achieved with one round of macromolecular synthesis. However, most of the antiviral effect directed against mengovirus and vaccinia virus seemed to require more than one round. These results suggest that IFN-α/βinduces two different antiviral states: one requiring one round of synthesis which is primarily responsible for the inhibition observed for VSV; and another requiring more than one round of synthesis which is primarily responsible for the inhibition observed for mengovirus and vaccinia virus.
