Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake.
Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake.
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DOI：
10.3389/fendo.2018.00328
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发表时间：
2018
影响因子：
5.2
通讯作者：
Knauf C
中科院分区：
文献类型：
--
作者：
Abot A;Cani PD;Knauf C
肠道是体内生物活性肽的重要来源之一。除了它们在脑和/或外周组织中的直接作用之外，肠肽还可以对肠神经神经元产生影响。通过改变这些肽的内源性产生，人们可以预期改变“局部”生理学，如葡萄糖吸收，但也可以通过肠-脑轴产生“全局”作用。由于肠肽的各种来源（即，营养素、肠壁、肠道微生物群）和肠神经元群体的异质性，由两个伙伴之间的相互作用控制的潜在生理参数是多个的。本文就肠神经系统作为肠肽调控糖代谢和食物摄入的潜在靶点进行综述。将描述基于口服肠肽治疗2型糖尿病的潜在治疗策略。
The gut is one of the most important sources of bioactive peptides in the body. In addition to their direct actions in the brain and/or peripheral tissues, the intestinal peptides can also have an impact on enteric nervous neurons. By modifying the endogenousproduction of these peptides, one may expect modify the “local” physiology such as glucose absorption, but also could have a “global” action via the gut–brain axis. Due to the various origins of gut peptides (i.e., nutrients, intestinal wall, gut microbiota) and the heterogeneity of enteric neurons population, the potential physiological parameters control by the interaction between the two partners are multiple. In this review, we will exclusively focus on the role of enteric nervous system as a potential target of gut peptides to control glucose metabolism and food intake. Potential therapeutic strategies based on per os administration of gut peptides to treat type 2 diabetes will be described.