THE TECUMSEH STUDY .15. ROTAVIRUS INFECTION AND PATHOGENICITY
THE TECUMSEH STUDY .15. ROTAVIRUS INFECTION AND PATHOGENICITY
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DOI：
10.1093/oxfordjournals.aje.a115396
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发表时间：
1989-10-01
影响因子：
5
通讯作者：
MONTO, AS
中科院分区：
文献类型：
--
作者：
KOOPMAN, JS;MONTO, AS
从1976年到1981年，在美国密歇根州特库姆塞的10%的家庭样本中，对轮状病毒感染和相关症状进行了前瞻性研究。感染确定使用抗体酶联免疫吸附试验（ELISA）的方法，设计了大量的血清收集半年一次。每周通过电话从确定的症状中确定疾病。轮状病毒季节期间的感染风险从1978年的4.8%变化到1980年的9.2%。2岁以下年龄组的风险为20.6%，45岁或以上年龄组的风险随着年龄的增长逐渐下降至3.6%。学龄前儿童占参考人群感染的不到20%。感染与出生后头两年的腹泻有关，并与以后的腹泻和呕吐有关。没有证据表明轮状病毒感染与胃肠-呼吸道综合征有关。感染的致病性、抗体的保护性和感染的社会经济相关因素每年都有明显的变化。1978年ELISA测定抗体的致病性和保护性明显高于其他年份。从1977年到1978年，感染的社会经济关系也发生了戏剧性的逆转。总之，这些发现表明不同的轮状病毒可能在这些年中占主导地位。
Rotavirus infection and associated symptoms were studied prospectively from 1976 through 1981 in a 10% sample of families in Tecumseh, Michigan (USA). Infection was determined using an antibody enzyme-linked immunosorbent assay (ELISA) method designed for us with large numbers of sera collected semiannually. Illness was identified from symptoms ascertained weekly by telephone. Risks of infection during a rotavirus season varied from 4.8% in 1978 to 9.2% in 1980. Risks were 20.6% in the under two years age group and decreased progressively with age to 3.6% in individuals aged 45 years or over. Preschool children accounted for less than 20% of the infections in the population of reference. Infection was associated with diarrhea in the first two years of life and with both diarrhea and vomiting later in life. There was no evidence for association of rotavirus infection with a gastrointestinal-respiratory syndrome. The pathogenicity of infection, the protectiveness of antibody, and the socioeconomic correlates of infection showed marked changes from year to year. In 1978, there was a dramatically higher pathogenicity and a greater protectiveness of ELISA measured antibody than in other years. There was also a dramatic reversal in the socioeconomic relations of infection from 1977 to 1978. Taken together, these findings suggest that differnt rotaviruses might have predominated in these years.