INSULIN-LIKE GROWTH-FACTOR-BINDING PROTEIN-3 IS DECREASED IN EARLY-STAGE OPERABLE PREMENOPAUSAL BREAST-CANCER
INSULIN-LIKE GROWTH-FACTOR-BINDING PROTEIN-3 IS DECREASED IN EARLY-STAGE OPERABLE PREMENOPAUSAL BREAST-CANCER
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DOI：
10.1002/ijc.2910620306
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发表时间：
1995-07-28
影响因子：
6.4
通讯作者：
HART, AAM
中科院分区：
文献类型：
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作者：
BRUNING, PF;VANDOORN, J;HART, AAM
胰岛素样生长因子I （IGF-I）是体外培养的人乳腺癌细胞的有效丝裂原。在循环中，大部分igf - 1与igf结合蛋白3 （IGFBP-3）结合。这种高亲和力结合被认为对igf - 1的生物活性具有重要的限制作用。为了评估IGF-I与受体结合的有效性，我们测定了IGF-I和IGFBP-3的血清水平以及IGF-I/IGFBP-3的比值。在一项病例对照研究中，150名年龄在38岁至75岁之间的i期或ii期乳腺癌患者在手术前（76人）或手术后一个月（74人）进行了调查。以人群为基础的对照组由44名同龄无乳腺癌的女性组成。报告患有糖尿病或其他激素异常的妇女被排除在外。绝经前患者血清IGF-I浓度升高，IGFBP-3水平降低，IGF-I/IGFBP-3比值升高。在调整了年龄、家族史、身高、体重指数、体脂分布和血清c肽水平后，IGF-I/IGFBP-3比值也是一个显著的乳腺癌危险因素。与igf - 1 /IGFBP-3水平最低的五分位数相比，最高的五分位数的相对风险为7.34。肿瘤的存在与否对这些结果没有影响。绝经前妇女血液循环中可用igf - 1水平的增加可能有助于乳腺癌的发展。(C) 1995 Wiley-Liss, Inc。
Insulin-like growth factor I (IGF-I) is a potent mitogen for human breast-cancer cells in vitro. In circulation, most of IGF-I is bound to IGF-binding protein 3 (IGFBP-3). This high-affinity binding is thought to have an important limiting effect on the availability of IGF-I for biological activity. To assess the availability of IGF-I for receptor binding, we determined serum levels of IGF-I and IGFBP-3 and IGF-I/IGFBP-3 ratios. In a case-control study, 150 women aged 38 to 75 years presenting with stage-I or -II breast cancer were investigated just prior to surgery (n = 76), or to irradiation one month after surgery (n = 74). The population-based control group consisted of 44 women of the same age having no breast cancer. Women reporting diabetes mellitus or other hormonal abnormalities were excluded. Premenopausal cases showed elevated IGF-I serum concentrations, decreased IGFBP-3 levels and increased IGF-I/IGFBP-3 ratios. The IGF-I/IGFBP-3 ratio was a significant breast-cancer risk factor, also after adjustment for age, family history, height, body-mass index, body-fat distribution, and serum levels of C-peptide. The relative risk was 7.34 for the highest compared with the lowest quintile of IGF-I/IGFBP-3. The presence or absence of tumor had no influence on these results. Increased levels of available IGF-I in the circulation of pre-menopausal women may contribute to the development of breast cancer. (C) 1995 Wiley-Liss, Inc.