Sudden adult death syndrome and other non-ischaemic causes of sudden cardiac death
Sudden adult death syndrome and other non-ischaemic causes of sudden cardiac death
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DOI：
10.1136/hrt.2004.045518
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发表时间：
2006-03-01
期刊：
影响因子：
5.7
通讯作者：
Sheppard, MN
中科院分区：
文献类型：
--
作者：
Fabre, A;Sheppard, MN
目的：评估15岁以上英国人群（包括老年患者）的非动脉粥样硬化性心脏死亡，并强调猝死中结构正常心脏的概念。方法：前瞻性收集英国验尸官提交的成人猝死的病理学数据。结果：本文对1994 ~ 2003年453例猝死病例进行了回顾性分析，其中男278例（61.4%），女175例（38.6%），年龄15 ~ 81岁。在这两个年龄组（35岁）中，男性都占多数。超过一半的心脏（n = 269，59.3%）结构正常。在其他40.7%的患者中，发现了心脏异常，包括：（1）心肌病（23%），如特发性纤维化、左心室肥大、肥厚型心肌病、扩张型心肌病和致瘤性右心室发育不良;（2）炎症性疾病（3）冠状动脉非粥样硬化性病变结论：猝死心脏结构正常的概念和需要组织学检查，以发现潜在的疾病是突出的。在尸检发现心脏正常的情况下，亲属需要接受心脏病和遗传筛查。
Objective: To evaluate non-atherosclerotic cardiac deaths in the UK population aged over 15 years including elderly patients and to highlight the concept of the structurally normal heart in sudden death.Methods: Pathological data were collected prospectively for sudden adult deaths referred by UK coroners.Results: 453 cases of sudden death from 1994 to 2003 ( 278 men (61.4%) and 175 women (38.6%), age range 15 - 81 years) were reviewed. Males predominated in both age groups ( 35 years). More than half of the hearts ( n = 269, 59.3%) were structurally normal. In the other 40.7%, cardiac abnormalities were noted, which included: ( 1) cardiomyopathies (23%) such as idiopathic fibrosis, left ventricular hypertrophy, hypertrophic cardiomyopathy, dilated cardiomyopathy, and arrhythmogenic right ventricular dysplasia; ( 2) inflammatory disorders (8.6%) including lymphocytic myocarditis and cardiac sarcoidosis; ( 3) non-atheromatous abnormalities of coronary arteries (4.6%); ( 4) valve diseases; and ( 5) miscellaneous and rare causes.Conclusion: The concept of the structurally normal heart in sudden death and the need for histological examination to detect underlying disease is highlighted. Relatives need to be referred for cardiological and genetic screening in cases of normal hearts found at necropsy.