GASTRITIS DUE TO SPIRAL SHAPED BACTERIA OTHER THAN HELICOBACTER-PYLORI - CLINICAL, HISTOLOGICAL, AND ULTRASTRUCTURAL FINDINGS
GASTRITIS DUE TO SPIRAL SHAPED BACTERIA OTHER THAN HELICOBACTER-PYLORI - CLINICAL, HISTOLOGICAL, AND ULTRASTRUCTURAL FINDINGS
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DOI：
10.1136/gut.32.2.137
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发表时间：
1991-02-01
期刊：
影响因子：
24.5
通讯作者：
BORCHARD, F
中科院分区：
文献类型：
--
作者：
HEILMANN, KL;BORCHARD, F
对胃活检标本中幽门螺杆菌的深入组织学研究导致在人胃粘膜中检测到其他螺旋形细菌。 报告了 39 例患者（占观察期间进行的所有胃活检的 0.25%）的临床和形态学结果，其中 34 例患者（87.2%）主诉上腹部不适。 5 名患者（12.8%）患有慢性胃炎，34 名患者（87.2%）患有慢性活动性胃炎。 通过光学显微镜可以看到胃小凹深处和细胞内的生物体。 扫描和透射电子显微镜结果显示细菌侵入并损伤胃粘膜细胞。 这些生物体类似于猫、狗和非人类灵长类动物胃中发现的螺旋形细菌。 在用铋盐治疗四个星期后，八名患者没有检测到微生物。 微生物的消失与慢性活动性胃炎及其症状的消退同时发生。
An intensive histological search for Helicobacter pylori in gastric biopsy specimens has led to the detection of other spiral shaped bacteria in the human gastric mucosa. The clinical and morphological findings of 39 cases (0.25% of all gastric biopsies performed in the observation period) are reported for 34 patients (87.2%) complaining of upper abdominal discomfort. Five patients (12.8%) had chronic gastritis and 34 (87.2%) chronic active gastritis. The organisms were seen by light microscopy deep in the gastric foveolae and intracellularly. The scanning and transmission electron microscopic findings show bacteria which invade and damage gastric mucosal cells. These organisms are similar to the spiral shaped bacteria found in the stomachs of cats and dogs and non-human primates. In eight patients organisms were not detected after four weeks of treatment with bismuth salts. The disappearance of the organisms coincided with resolution of the chronic active gastritis and the symptoms.