Beta-trace protein is not superior to cystatin C for the estimation of GFR in patients receiving corticosteroids
Beta-trace protein is not superior to cystatin C for the estimation of GFR in patients receiving corticosteroids
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DOI：
10.1016/j.clinbiochem.2007.11.012
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发表时间：
2008-03-01
影响因子：
2.8
通讯作者：
Bokenkamp, Arend
中科院分区：
文献类型：
--
作者：
Abbink, Floor C. H.;Laarrnan, Celeste A. R. C.;Bokenkamp, Arend
目的：比较皮质类固醇治疗对两种 GFR 内源性标志物胱抑素 C (Cys) 和 β-微量蛋白 (bTP) 诊断性能的影响。 设计和方法：在总共 193 项儿科菊粉清除率研究中，随机抽取 85 项无类固醇研究来建立 GFR 预测方程 (eGFR)，用于比较其余 76 项研究 无类固醇和 32 项类固醇阳性研究（中位泼尼松剂量 33.0 mg m(-2) 天(-1)）。结果：我们发现泼尼松剂量与 eGFR(beta TP) 呈正相关（b=0.414，p=0.0002），与 eGFR(cys) 呈负相关（b=-0.208，p=0.0091）。在类固醇阳性 (b=6.260, p=0.010) 和类固醇阴性 (b=6.845, p=0.012) 中，只有 Cys 独立预测 GFR 低于 90 mL min(-1) 1.73 m(-2)。糖皮质激素治疗不会影响 Cys 测量 GFR 30% 范围内估计 GFR 的准确性，而 bTP 的准确性较低（65.6% vs. 81.6%，p=0.08）。结论：糖皮质激素对 Cys 诊断准确性的影响小于 bTP。 (C)0 2007 加拿大临床化学家协会。由爱思唯尔公司出版。保留所有权利。
Objectives: Comparison of the effect of corticosteroid therapy on the diagnostic performance of cystatin C (Cys) and beta-trace protein (bTP), two endogenous markers of GFR.Design and methods: Out of a total of 193 pediatric inulin clearance studies, a random sample of 85 steroid-free studies served to establish GFR prediction equations (eGFR), which were used to compare the remaining 76 steroid-free and 32 steroid-positive studies (median prednisone dose 33.0 mg m(-2) day(-1)).Results: We found a positive relationship between prednisone dose and eGFR(beta TP) (b=0.414, p=0.0002) and a negative relationship with eGFR(cys) (b=-0.208, p=0.0091). Only Cys independently predicted GFR below 90 mL min(-1) 1.73 m(-2), both in steroid-positives (b=6.260, p=0.010) and steroid-negatives (b=6.845, p=0.012). Glucocorticoid therapy did not affect the accuracy in estimating GFR within 30% of measured GFR for Cys, while accuracy was lower with bTP (65.6% vs. 81.6%, p=0.08).Conclusion: Glucocorticoids have less impact on the diagnostic accuracy of Cys than bTP. (C)0 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.