433 MHz Lithium Niobate Microbalance Aptamer-Coated Whole Zika Virus Sensor With 370 Hz/ng Sensitivity
433 MHz Lithium Niobate Microbalance Aptamer-Coated Whole Zika Virus Sensor With 370 Hz/ng Sensitivity
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DOI：
10.1109/jsen.2019.2961611
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发表时间：
2020-04-15
影响因子：
4.3
通讯作者：
Tabib-Azar, Massood
中科院分区：
文献类型：
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作者：
Dolai, Subhashish;Tabib-Azar, Massood
三种不同的微天平被涂上带有硫醇末端的适配子，旨在附着在整个寨卡病毒的衣壳蛋白上。第一台微天平是一台5 MHz商用AT-Cut(QSense)石英微天平，灵敏度为1赫兹/纳克，最小可检测信号(MDS)为1纳克。第二个传感器是从通信滤波器中提取的10 MHz AT-Cut石英传感器。灵敏度为10 Hz/ng，MDS为0.1 ng。第三个传感器是433 MHz的铌酸锂(LiNbO_3)传感器，该传感器也是从通信过滤器中提取的。它的灵敏度为370 Hz/ng，平均吸光度为2.7pg。这些研究证实了适配子与传感器表面和寨卡病毒的结合。它们也清楚地显示了使用LiNbO_3高频微天平的优势。
Three different microbalances were coated with aptamers with thiol termination designed to attach to the capsid proteins of the whole Zika virus. The first microbalance was a 5 MHz commercial AT-cut (QSense) quartz microbalance that showed 1 Hz/ng sensitivity with minimum detectable signal (MDS) of 1 ng. The second sensor was a 10 MHz AT-cut quartz sensor that was extracted from a communication filter. It had 10 Hz/ng sensitivity and MDS of 0.1 ng. The third sensor was a 433 MHz Lithium Niobate (LiNbO3) sensor that was also extracted from a communication filter. It had 370 Hz/ng sensitivity and 2.7 pg MDS. These studies verify binding of the aptamers to the sensor surface and the Zika virus. They also clearly show the advantage of using the LiNbO3 high frequency microbalance.