The application of computer simulation in the genesis and development of intracranial aneurysms.
The application of computer simulation in the genesis and development of intracranial aneurysms.
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DOI：
10.3233/thc-2005-13407
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发表时间：
2005-07
期刊：
影响因子：
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通讯作者：
Yixiang Feng;S. Wada;K. Tsubota;Takami Yamaguchi
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文献类型：
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作者：
Yixiang Feng;S. Wada;K. Tsubota;Takami Yamaguchi
颅内动脉瘤的发生和发展一直受到关注，但仍不清楚。在本研究中，我们通过构建弯曲动脉的计算模型来模拟颅内动脉瘤的进展。假设高于阈值的高局部壁剪切应力将导致动脉壁机械性能的退化。这种退化效应甚至在壁面剪应力已经变得低于阈值之后仍可能持续，在本研究中被称为“时间剩余效应”。我们使用两种假设进行了几组研究，观察到动脉瘤发展是高壁剪切应力、壁退化和壁变形之间相互作用的结果。在具有“时间剩余效应”的动脉瘤生长过程中，动脉瘤高度的增长在以后的步骤中加快。它的结论是，计算机模拟可以深入了解的病理生理学的血管起始和生长，并有助于澄清某些血流动力学参数的作用。
The genesis and development of intracranial aneurysm have long been of interest but remain not understood. In the present study we simulate the progression of intracranial aneurysms by constructing a computational model of a curved artery. It is hypothesized that high local wall shear stress above a threshold value will lead to degeneration of the arterial wall mechanical properties. And this degenerative effect may continue even after the wall shear stress has become lower than the threshold, which is referred to as the "time remaining effect" in this study. We performed several groups of studies using both assumptions and aneurysm development is observed as result of the interplay between high wall shear stress, wall degeneration and wall deformation. In the growth of aneurysms with "time-remaining effect", the increase of aneurysmal height accelerates in later steps. It is concluded that computer simulation can yield insight into the understanding of the pathophysiology of aneurysmal initiation and growth, and help in clarifying the role of certain hemodynamic parameters.