Cancer inhibition by green tea
Cancer inhibition by green tea
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DOI：
10.1016/s0027-5107(97)00310-2
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发表时间：
1998-06-18
影响因子：
2.3
通讯作者：
Nakachi, K
中科院分区：
文献类型：
--
作者：
Fujiki, H;Suganuma, M;Nakachi, K
在日本，绿茶现在是公认的防癌产品。本文讨论了绿茶和茶多酚的主要成分--表没食子儿茶素没食子酸酯(EGCG)的几个重要特征。EGCG等茶多酚对人肺癌细胞株PC-9的生长有抑制作用，并使其发生G(2)/M期阻滞。H-3-EGCG灌胃给药。小鼠胃插管实验表明，EGCG和绿茶提取物在皮肤、胃、十二指肠、结肠、肝脏、肺和胰腺等先前已证明具有抗癌作用的器官中发现了少量的H-3活性。与每天饮用3杯以下绿茶的患者相比，每天饮用超过10杯绿茶的女性患者患癌症的时间推迟了8.7年，男性患者的癌症发病时间推迟了3.0年。简要讨论了EGCG抑制肿瘤坏死因子-α释放的作用机制。(C)1998 Elsevier Science B.V.保留所有权利。
Green tea is now an acknowledged cancer preventive in japan. This paper discusses several important features of (-)-epigallocatechin gallate (EGCG), the main constituent of green tea and tea polyphenols. EGCG and other tea polyphenols inhibited growth of human lung cancer cell line, PC-9 cells with G(2)/M arrest. H-3-EGCG administered by p.o. intubation into mouse stomach revealed that small amounts of H-3-activity were found in various organs where EGCG and green tea extract had previously demonstrated their anticarcinogenic effects, such as skin, stomach, duodenum, colon, liver, lung and pancreas. Cancer onset of patients who had consumed over 10 cups of green tea per day was 8.7 years later among females and 3.0 years later among males, compared with patients who had consumed under three cups per day. The mechanisms of action of EGCG were briefly discussed with regard to inhibition of tumor necrosis factor-alpha (TNF-alpha) release. (C) 1998 Elsevier Science B.V. All rights reserved.