Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network
Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network
复制标题
DOI：
10.1073/pnas.1120754109
复制
发表时间：
2012-03-13
影响因子：
11.1
通讯作者：
Gage, Fred H.
中科院分区：
文献类型：
--
作者：
Li, Yan;Aimone, James B.;Gage, Fred H.
成人海马体的齿状回（DG）中不断产生新的神经元，并且新的颗粒细胞（GC）已被证明对于学习和记忆的多个方面是必需的。尽管如此，关于成熟神经元突触输入的解剖学和生理学发育的可用信息有限，限制了我们对新GC如何影响认知的理解。在这里，我们使用光刺激来演示解剖学上隔离的抑制输入发育成成熟 GC 的时间过程。然后我们证明，在计算模型中，抑制的逐渐发展足以驱动年轻神经元学习新信息。最后，我们通过使用切片生理学来验证这一模型观察，以显示抑制如何调节年轻 GC 的放电概率和可塑性。综合起来，这些数据表明，未成熟 GC 的独特连接性赋予它们与 DG 回路中成熟神经元不同的功能作用，这种区别可能是海马网络中新神经元的许多拟议功能的基础。
New neurons are continuously generated in the dentate gyrus (DG) in the adult hippocampus, and new granule cells (GCs) have been shown to be necessary for several aspects of learning and memory. Nonetheless, the limited information available regarding the anatomical and physiological development of synaptic inputs onto maturing neurons has restricted our understanding of how new GCs affect cognition. Here, we use photostimulation to demonstrate the time course by which anatomically isolated inhibitory inputs develop onto maturing GCs. We then show that the gradual development of inhibition is sufficient in a computational model to drive learning of novel information in young neurons. Finally, we validate this model observation by using slice physiology to show how inhibition regulates firing probability and plasticity in young GCs. Combined, these data demonstrate that the unique connectivity of immature GCs affords them a functional role that is different from mature neurons in the DG circuit, a distinction that potentially underlies many of the proposed functions of new neurons in the hippocampal network.