Stem-cell homeostasis and growth dynamics can be uncoupled in the Arabidopsis shoot apex
Stem-cell homeostasis and growth dynamics can be uncoupled in the Arabidopsis shoot apex
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DOI：
10.1126/science.1116261
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发表时间：
2005-10-28
期刊：
影响因子：
56.9
通讯作者：
Meyerowitz, EM
中科院分区：
文献类型：
--
作者：
Reddy, GV;Meyerowitz, EM
茎尖分生组织（SAM）是位于每个茎尖并提供茎细胞的干细胞的集合。它被划分为功能区。分生组织顶端的中心区（CZ）是CLAVATA 3（CLV 3）基因的表达域，该基因编码跨膜受体激酶CLAVATA 1的推定配体，CLAVATA 1在位于CZ正下方的肋分生组织（RM）细胞中具有活性。我们在这里表明，CLV 3限制其自身的表达域（CZ），通过阻止分化的外周带细胞（PZ），其中周围的CZ，到CZ凯尔特人和限制整体SAM的大小由一个单独的，tong-range影响细胞分裂率。
The shoot apical meristem (SAM) is a collection of stem cells that resides at the tip of each shoot and provides the cells of the shoot. It is divided into functional regions. The central zone (CZ) at the tip of the meristem is the domain of expression of the CLAVATA3 (CLV3) gene, encoding a putative ligand for a transmembrane receptor kinase, CLAVATA1, active in cells of the rib meristem (RM), located just below the CZ. We show here that CLV3 restricts its own domain of expression (the CZ) by preventing differentiation of peripheral zone cells (PZ), which surround the CZ, into CZ Celts and restricts overall SAM size by a separate, tong-range effect on cell division rate.