Hydrogels of poly(ethylene glycol): mechanical characterization and release of a model drug
Hydrogels of poly(ethylene glycol): mechanical characterization and release of a model drug
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DOI：
10.1016/s0168-3659(97)00191-0
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发表时间：
1998-03-02
影响因子：
10.8
通讯作者：
Couarraze, G
中科院分区：
文献类型：
--
作者：
Iza, M;Stoianovici, G;Couarraze, G
以聚乙二醇、六亚甲基二异氰酸酯和1，2，6-己三醇为原料，按化学计量比合成了温敏聚合物网络。通过改变1，2，6-己三醇的用量和聚乙二醇摩尔质量，制备了一系列不同交联度的网络。所得网络的特征是它们在水中的平衡溶胀度与温度的关系以及它们的杨氏模数。对于每个网络，估计了交联物之间的分子量。根据标度定律分析了水凝胶的结构，发现用PEG1500和PEG6000水凝胶得到的结果与理论预测是一致的，而用PEG400水凝胶得到的结果是不一致的。通过测定氯化乙酰丁醇的扩散系数并分析温度对扩散系数的影响，研究了聚乙二醇水凝胶的释药特性。最后，这些释放特性与水凝胶的溶胀和结构特性相关联。(C)1998年爱思唯尔科学公司。
Thermosensitive polymer networks were synthesized from poly(ethylene glycol), hexamethylene diisocyanate and 1,2,6-hexanetriol in stoichiometric proportions. By varying the amount of 1,2,6-hexanetriol and the molar mass of the poly(ethylene glycol), a wide range of networks with different crosslinking densities was prepared. The networks obtained were characterized by the temperature dependence of their degree of equilibrium swelling in water and by their Young's moduli. For each network, the molecular weight between crosslinks was estimated. The structure of the hydrogels was analysed with respect to scaling laws, and it was found that the results obtained with PEG 1500 and PEG 6000 hydrogels are in agreement with theoretical predictions, whereas those obtained with PEG 400 hydrogels are in disagreement. The release properties of PEG hydrogels were studied by the determination of the diffusion coefficient for acebutolol chlorhydrate and by an analysis of the effect of temperature on these coefficients. Finally, these release properties were correlated with the swelling and structural properties of the hydrogels. (C) 1998 Elsevier Science B.V.