Stability of a Vesicular Stomatitis Virus-Vectored Ebola Vaccine
Stability of a Vesicular Stomatitis Virus-Vectored Ebola Vaccine
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DOI：
10.1093/infdis/jiv532
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发表时间：
2016-03-15
影响因子：
6.4
通讯作者：
Gjoen, Tor
中科院分区：
文献类型：
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作者：
Arnemo, Marianne;Watle, Sara Sofie Viksmoen;Gjoen, Tor
减毒水泡性口炎病毒载体埃博拉疫苗rVSV-ZEBOV目前正在西非进行临床试验。由于在农村地区维持冷链具有挑战性，因此对rVSV-ZEBOV疫苗在不同温度下的短期和长期稳定性进行了检查。由于在本实验开始时尚未确定最佳疫苗剂量，因此检测了不同的稀释度。结果表明，原始疫苗制剂在4 ℃下稳定1周，在25 ℃下稳定24小时。疫苗的稳定性受到高温和稀释的影响。
The live attenuated vesicular stomatitis virus-vectored Ebola vaccine rVSV-ZEBOV is currently undergoing clinical trials in West Africa. The vaccine is to be stored at -70 degrees C or less. Since maintaining the cold chain is challenging in rural areas, the rVSV-ZEBOV vaccine's short-term and long-term stability at different temperatures was examined. Different dilutions were tested since the optimal vaccine dosage had not yet been determined at the start of this experiment. The results demonstrate that the original vaccine formulation was stable for 1 week at 4 degrees C and for 24 hours at 25 degrees C. The stability of the vaccine was compromised by both high temperatures and dilution.