The targets of CAPRI Rounds 13-19
The targets of CAPRI Rounds 13-19
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DOI：
10.1002/prot.22774
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发表时间：
2010-11-15
影响因子：
2.9
通讯作者：
Janin, Joel
中科院分区：
文献类型：
--
作者：
Janin, Joel
2007年6月至2009年11月期间，共进行了七轮卡普里预测，共涉及14个目标。除了蛋白酶/抑制剂复合物和与G蛋白的复合物外，一些靶点还显示出新的特征，对预测因子提出了新的挑战：与RNA的复合物，从头开始构建的亮氨酸拉链和人类设计的蛋白质。九个目标是未绑定的或需要建模;其他五个有绑定组件。对13个进行了评估，结果显示，预测者和评分者组提交了其中8个的2星或3星（中等或高质量）模型，3个提交了1星（可接受）模型，但未结合RNA复合物和另一个未结合靶标失败。Proteins 2010; 78：3067-3072. (C)2010 Wiley-Liss，Inc.
Seven rounds of CAPRI predictions with a total of 14 targets were held in the period June 2007 November 2009. In addition to protease/inhibitor complexes and complexes with G-proteins, some of the targets displayed novel features presenting new challenges to the predictors: a complex with RNA, a leucine zipper to be built ab initio, and a human-designed protein. Nine targets were unbound or required model building; the other five had a bound component. Thirteen were assessed, and the results show that the predictor and scorer groups submitted two- or three-star (medium or high quality) models for eight of them, one-star (acceptable) models for three but failed on the unbound RNA complex and another unbound target. Proteins 2010; 78:3067-3072. (C) 2010 Wiley-Liss, Inc.