23Na Magnetic Resonance Imaging of Tissue Sodium
23Na Magnetic Resonance Imaging of Tissue Sodium
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DOI：
10.1161/hypertensionaha.111.183517
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发表时间：
2012-01-01
期刊：
影响因子：
8.3
通讯作者：
Titze, Jens
中科院分区：
文献类型：
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作者：
Kopp, Christoph;Linz, Peter;Titze, Jens
高血压与全身钠（Na+）调节紊乱有关;然而，测量Na+在体内的分布是困难的。采用Na-23磁共振波谱（Na-23-MR）和成像技术（Na-23-MRI），分别在9.4T和3 T下对动物和人体骨骼肌和皮肤中Na+含量进行定量分析。我们比较了Na-23-MRI数据与动物和人体组织中通过化学分析测量的实际组织Na+含量。然后，我们定量组织Na+含量在正常人和原发性醛固酮增多症患者。我们发现，与正常女性和男性相比，醛固酮增多症患者的肌肉Na+含量增加了29%。该组织Na+在成功治疗后被动员，而没有伴随体重减轻。我们认为，经过进一步的改进，这个工具可以促进了解钠离子积累和高血压之间的关系。此外，随着其他技术的进步，未来的临床应用可能是可能的。（高血压。2012; 59：167-172）。
Hypertension is linked to disturbed total-body sodium (Na+) regulation; however, measuring Na+ disposition in the body is difficult. We implemented Na-23 magnetic resonance spectroscopy (Na-23-MR) and imaging technique (Na-23-MRI) at 9.4T for animals and 3T for humans to quantify Na+ content in skeletal muscle and skin. We compared Na-23-MRI data with actual tissue Na+ content measured by chemical analysis in animal and human tissue. We then quantified tissue Na+ content in normal humans and in patients with primary aldosteronism. We found a 29% increase in muscle Na+ content in patients with aldosteronism compared with normal women and men. This tissue Na+ was mobilized after successful treatment without accompanying weight loss. We suggest that, after further refinements, this tool could facilitate understanding the relationships between Na+ accumulation and hypertension. Furthermore, with additional technical advances, a future clinical use may be possible. (Hypertension. 2012; 59: 167-172.)