Pika Population Density Is Associated with the Composition and Diversity of Gut Microbiota.
Pika Population Density Is Associated with the Composition and Diversity of Gut Microbiota.
复制标题
鼠兔种群密度与肠道微生物群的组成和多样性有关
DOI：
10.3389/fmicb.2016.00758
复制
发表时间：
2016
影响因子：
5.2
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Li H;Qu J;Li T;Li J;Lin Q;Li X
宿主种群密度与社会互动的强度或身体接触的频率呈正相关，因此可能影响个体之间的微生物传播。然而，宿主密度和肠道微生物群之间的关系仍然未知。在这里，我们的特点是肠道菌群的高原鼠兔（鼠兔）在野生实验场与不同的主机人口密度。某些肠道微生物的丰度与宿主密度显著相关，如瘤胃球菌科、毛螺菌科和葡萄球菌科。有趣的是，宿主密度与肠道微生物群落的α多样性（香农多样性和观察到的物种）呈正相关。高密度组内个体间肠道菌群比低密度组更相似。即使在控制了性别、体重、饮食和地理位置之后，宿主密度也能显著解释肠道微生物群的变化。基于PICRUSt宏基因组预测，观察到宿主密度与参与细胞过程、环境信息处理和代谢的12个基因功能的相对丰度之间正相关。这些结果表明宿主密度作为塑造高原鼠兔肠道微生物组成和多样性的一个因素的重要性，并可能进一步帮助我们了解肠道微生物群的社会传播。
Host population density is positively associated with the strength of social interactions or the frequency of physical contacts, and thus potentially influences microbial transmission among individuals. However, the relationship between host density and gut microbiota remains unknown. Here, we characterized the gut microbiota of plateau pikas (Ochotona curzoniae) in wild experimental fields with different host population densities. The abundance of some gut microbes significantly correlated with host density, such as Ruminococcaceae, Lachnospiraceae, and Staphylococcaceae. Intriguingly, host density was positively correlated with alpha diversity (Shannon diversity and observed species) of gut microbial communities. The inter-individual gut microbiota within high-density groups were more similar to each other than those of low-density groups. Host density significantly explained the variations in the gut microbiota, even after controlling sex, weight, diet and geographical locations. Based on the PICRUSt metagenome prediction, positive correlations were observed between host density and the relative abundances of 12 gene functions involved in cellular processes, environmental information processing and metabolism. These results indicate the importance of host density as a factor in shaping gut microbial composition and diversity in plateau pikas, and may further help us understand the social transmission of gut microbiota.