Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death
Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death
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DOI：
10.1038/sj.onc.1203429
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发表时间：
2000-03-02
期刊：
影响因子：
8
通讯作者：
Shiraki, K
中科院分区：
文献类型：
--
作者：
Suzuki, A;Ito, T;Shiraki, K
Caspase3是Fas介导的细胞死亡所必需的死亡因子，其在细胞内的失活是通过与线粒体上的p21或与PAP家族成员ILP的相互作用而启动的，Survivin也是HAP家族的成员，在胚胎发育和肿瘤细胞中特异表达，并抑制细胞死亡信号。Survivin还与细胞周期调节因子CDK4相互作用，导致CDK2/Cyclin E活化和Rb磷酸化，作为Survivin/CDK4复合体形成的结果，p21从与CDK4的复合体中释放出来，并与线粒体proaspase 3相互作用，抑制Fas介导的细胞死亡，我们认为Survivin通过与CDk4相互作用支持Proaspase 3/p21复合体的形成，从而抑制细胞死亡信号。
Caspase 3 is ran essential death factor for the Fas-mediated cell death, and its inactivation in cells is initiated by an interaction with p21 on mitochondria or with PAP family member ILP, Survivin is also a member of HAP family and is specifically expressed during embryogenesis and in tumor cells and suppresses cell death signaling, In our current study, we demonstrated that Survivin translocation into the nucleus is dependent on Fas stimulation and cell proliferation. Survivin also interacts with the cell cycle regulator Cdk4, leading to Cdk2/Cyclin E activation and Rb phosphorylation, As a result of Survivin/Cdk4 complex formation, p21 is released from its complex with Cdk4 and interacts with mitochondrial procaspase 3 to suppress Fas-mediated cell death, Here, we propose that Survivin supports procaspase 3/p21 complex formation as a result of interaction with Cdk4 resulting in suppression of cell death signaling.