Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer
Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer
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DOI：
10.1002/jso.23075
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发表时间：
2012-09-01
影响因子：
2.5
通讯作者：
Ishikawa, Osamu
中科院分区：
文献类型：
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作者：
Kishi, Kentaro;Fujiwara, Yoshiyuki;Ishikawa, Osamu
背景 本研究评估了使用口服 5-氨基乙酰丙酸 (ALA) 进行光动力诊断 (PDD) 检测晚期胃癌腹膜转移的有效性。方法 首先，对小鼠腹膜转移模型中常规白光（WL）和ALA诱导荧光（ALA-F）下可见的腹膜转移结节数量进行定量，以比较肿瘤检出率。接下来，使用 ALA-PDD 对 13 例患有浆膜侵犯肿瘤的晚期胃癌患者进行分期腹腔镜检查 (SL)，并将 ALA-PDD 的检测灵敏度与使用 WL 的观察结果进行比较。结果 ALA-F 的肿瘤检出率显着高于 WL 的检出率（分别为 72% 和 39%，P？
Background This study evaluated the usefulness of photodynamic diagnosis (PDD) using oral 5-aminolevulinic acid (ALA) for the detection of peritoneal metastases in advanced gastric cancer. Method First, the numbers of peritoneal metastatic nodules that were visible under conventional white light (WL) and ALA-induced fluorescence (ALA-F) were quantified in a mouse model of peritoneal metastasis to compare the tumor detection rate. Next, staging laparoscopy (SL) using ALA-PDD was performed in 13 advanced gastric cancer patients with serosa-invading tumors, and the detection sensitivity of ALA-PDD was compared to the observations using WL. Results The tumor detection rate using ALA-F was significantly higher than the detection rate using WL (72% vs. 39%, respectively, P?