Thioredoxin Network in Plant Mitochondria: Cysteine S-Posttranslational Modifications and Stress Conditions.
Thioredoxin Network in Plant Mitochondria: Cysteine S-Posttranslational Modifications and Stress Conditions.
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DOI：
10.3389/fpls.2020.571288
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发表时间：
2020
影响因子：
5.6
通讯作者：
Sevilla F
中科院分区：
文献类型：
--
作者：
Martí MC;Jiménez A;Sevilla F
植物是固着生物，具有不同的适应机制，使它们能够在不利的情况下生存。其中，活性氧和氮（ROS，RNS）和H2S不仅是细胞发育和分化的组成部分，而且是参与生物和非生物攻击反应的信号通路的组成部分。对这些信号分子产生的蛋白质的翻译后修饰（PTM）的研究揭示了对不同细胞区室中许多代谢途径所涉及的特定靶点的调节。这些修饰能够将由暴露于应激情况引起的氧化还原状态的不平衡转化为级联反应，最终使植物能够科普不利条件。在这篇综述中，我们给出了一个广义的视觉生产的ROS，RNS，和H2S在植物线粒体。我们专注于如何主要的线粒体过程主要是电子传递链，三羧酸循环和光呼吸的影响，由PTM的半胱氨酸残基，是由前面提到的信号分子在呼吸细胞器中产生。这些PTM包括正常和强制降解条件下的S-氧化、S-谷胱甘肽化、S-亚硝化和过硫化。我们特别关注线粒体硫氧还蛋白/过氧化物酶系统的氧化还原翻译后的目标和它对环境压力的反应。
Plants are sessile organisms presenting different adaptation mechanisms that allow their survival under adverse situations. Among them, reactive oxygen and nitrogen species (ROS, RNS) and H2S are emerging as components not only of cell development and differentiation but of signaling pathways involved in the response to both biotic and abiotic attacks. The study of the posttranslational modifications (PTMs) of proteins produced by those signaling molecules is revealing a modulation on specific targets that are involved in many metabolic pathways in the different cell compartments. These modifications are able to translate the imbalance of the redox state caused by exposure to the stress situation in a cascade of responses that finally allow the plant to cope with the adverse condition. In this review we give a generalized vision of the production of ROS, RNS, and H2S in plant mitochondria. We focus on how the principal mitochondrial processes mainly the electron transport chain, the tricarboxylic acid cycle and photorespiration are affected by PTMs on cysteine residues that are produced by the previously mentioned signaling molecules in the respiratory organelle. These PTMs include S-oxidation, S-glutathionylation, S-nitrosation, and persulfidation under normal and stress conditions. We pay special attention to the mitochondrial Thioredoxin/Peroxiredoxin system in terms of its oxidation-reduction posttranslational targets and its response to environmental stress.
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影响因子：
4.1
作者：
Bedhomme, Mariette;Adamo, Mattia;Trost, Paolo
通讯作者：
Trost, Paolo
影响因子：
6.4
作者：
Calderon, Aingeru;Sanchez-Guerrero, Antonio;Sevilla, Francisca
通讯作者：
Sevilla, Francisca
DOI：
10.1073/pnas.152168599
发表时间：
2002-07-23
影响因子：
11.1
作者：
Casagrande, S;Bonetto, V;Ghezzi, P
通讯作者：
Ghezzi, P
影响因子：
4.8
作者：
Beer, SM;Taylor, ER;Murphy, MP
通讯作者：
Murphy, MP
影响因子：
11.4
作者：
Calderón A;Ortiz-Espín A;Iglesias-Fernández R;Carbonero P;Pallardó FV;Sevilla F;Jiménez A
通讯作者：
Jiménez A