Searching for the mechanism(s) of ECT's therapeutic effect.
Searching for the mechanism(s) of ECT's therapeutic effect.
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DOI：
10.1097/yct.0000000000000121
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Sienaert P
中科院分区：
文献类型：
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作者：
McCall WV;Andrade C;Sienaert P
电休克疗法（ECT）的确切治疗机制仍未解决。几十年前的许多心理学理论已被证明是不正确的。在接下来的几年中，ECT 已被证明对大脑化学、区域大脑活动、脑电图睡眠阶段和神经发生具有许多可重复的影响。临床上，ECT已被证明具有抗抑郁、抗精神病、抗躁狂、抗帕金森病和抗惊厥作用。 ECT 的不同生物效应可能导致不同的临床效应，或者多种生物效应协同作用产生特定的临床效应。本文评论了一系列可能的机制，并指出了 ECT 机制研究的未来。
The exact therapeutic mechanism of action of electroconvulsive therapy (ECT) remains unresolved. Numerous psychological theories from decades ago have been proven untrue. In the ensuing years, ECT has been proven to have numerous reproducible effects on brain chemistry, regional brain activity, electroencephalographic sleep stages, and neurogenesis. Clinically, ECT has been shown to have antidepressant, antipsychotic, antimanic, antiparkinsonian, and anticonvulsive effects. It is possible that different biological effects of ECT are responsible for different clinical effects or that several biological effects in concert work together to produce a given clinical effect. This paper comments on the array of possible mechanisms and points toward the future of mechanistic research in ECT.