Identification of transcription factors activated in thymic epithelial cells during embryonic thymus development.
Identification of transcription factors activated in thymic epithelial cells during embryonic thymus development.
复制标题
胚胎胸腺发育过程中胸腺上皮细胞激活的转录因子的鉴定。
DOI：
10.1007/978-1-4939-0805-9_13
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
J.
中科院分区：
文献类型：
--
作者：
Akiyama;T.;Qin;J.;Ohshima;D. and Inoue;J.
许多免疫相关细胞的分化受转录因子（TF）的表达水平和激活状态控制。我们在这里描述了一种方法，以确定候选TF激活胸腺上皮细胞（TEC）在胚胎发育过程中。从野生型和突变小鼠的胎儿胸腺器官培养物中分离RNA，随后通过使用综合表达分析和计算机数据分析的组合进行分析，以预测可能被激活的TF。
Differentiation of many immune-related cells is controlled by the expression levels and the activation status of transcription factors (TFs). We here describe a method to identify candidate TFs activated during the development of thymic epithelial cells (TECs) in the embryo. RNAs are isolated from fetal thymic organ cultures of wild-type and mutant mice and are subsequently analyzed by using a combination of comprehensive expression analysis and in silico data analysis in order to predict the TFs that might be activated.
影响因子：
7.3
作者：
Akiyama T;Shinzawa M;Akiyama N
通讯作者：
Akiyama N