The 5-HT2C receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test
The 5-HT2C receptor agonist WAY-163909 decreases impulsivity in the 5-choice serial reaction time test
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DOI：
10.1016/j.bbr.2007.11.016
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发表时间：
2008-04-09
影响因子：
2.7
通讯作者：
Day, Mark
中科院分区：
文献类型：
--
作者：
Navarra, Rachel;Comery, Thomas A.;Day, Mark
在许多神经精神和神经退行性疾病中观察到冲动性增加。临床前证据表明，5-羟色胺5-HT 2C受体的拮抗作用可能会增加冲动性，从而导致激动剂可能发挥相互作用并减弱冲动行为的假设[1]。5-HT 2C激动剂。WAY-163909，在本论文中使用可变刺激持续时间和试验间间隔操作，在5选择系列反应时间测试中进行评估，旨在增加冲动性和减少注意力。WAY-163909治疗选择性地和剂量依赖性地降低冲动性，表明5-HT 2C受体的激动作用可用于调节冲动性为病理特征的疾病状态中的冲动性。(c)2007 Elsevier B. V.保留所有权利。
Increased impulsivity is observed across a number of neuropsychiatric and neurodegenerative diseases. Preclinical evidence has demonstrated that antagonism of the serotonin 5-HT2C receptor may act to increase impulsivity, leading to the hypothesis that an agonist may exert reciprocal effects and attenuate impulsive behavior [1]. The 5-HT2C agonist. WAY-163909, was evaluated in the present paper using a variable stimulus duration and inter-trial interval manipulation in the 5-choice serial reaction time test designed to increase impulsivity and decrease attention. WAY-163909 treatment selectively and dose-dependently decreased impulsivity suggesting that agonism of the 5-HT2C receptor may be useful for modulating impulsivity in disease states where impulsivity is a pathological feature. (c) 2007 Elsevier B.V. All rights reserved.