Hypoxia and cancer related pathology
Hypoxia and cancer related pathology
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缺氧与癌症相关病理学
DOI：
10.1016/j.canlet.2020.05.002
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发表时间：
2020-08-28
期刊：
影响因子：
9.7
通讯作者：
Chen，Yongbin
中科院分区：
文献类型：
--
作者：
Xiong，Qiuxia;Liu，Baiyang;Chen，Yongbin
低渗环境通常发生在高海拔地区，或在地下洞穴和深海栖息地。它们也在人类缺血和缺氧性实体瘤中病理性发生。各种癌症类型中的缺氧及其相关的分子机制与不良的临床结果相关。这篇综述将讨论缺氧如何影响肿瘤发生的两个方面，即直接的，细胞内在的致癌作用，以及间接影响肿瘤微环境的改变介导的肿瘤进展。我们还将讨论最近的进展，在确定缺氧相关因子（HIF）的功能作用，沿着其调节和下游靶基因，在癌症干细胞和治疗。重要的是，我们建议，使用收敛进化方案，以确定新的生物标志物缺氧适应和缺氧实体瘤作为一个重要的战略，在未来。
Hypoxic environments occur normally at high altitude, or in underground burrows and in deep sea habitats. They also occur pathologically in human ischemia and in hypoxic solid tumors. Hypoxia in various cancer types and its related molecular mechanisms are associated with a poor clinical outcome. This review will discuss how hypoxia can influence two aspects of tumorigenesis, namely the direct, cell-intrinsic oncogenic effects, as well as the indirect effects on tumor progression mediated by an altered tumor microenvironment. We will also discuss recent progress in identifying the functional roles of hypoxia-related factors (HIFs), along with their regulators and downstream target genes, in cancer stem cells and therapy. Importantly, we propose, using convergent evolution schemes to identify novel biomarkers for both hypoxia adaptation and hypoxic solid tumors as an important strategy in the future.