Repeated stretch-shortening contraction of the triceps surae attenuates muscle atrophy and liver dysfunction in a rat model of inflammation.
Repeated stretch-shortening contraction of the triceps surae attenuates muscle atrophy and liver dysfunction in a rat model of inflammation.
复制标题
小腿三头肌的反复拉伸-缩短可以减轻炎症大鼠模型中的肌肉萎缩和肝功能障碍。
DOI：
10.1113/ep088622
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Nakazato K.
中科院分区：
文献类型：
--
作者：
Sumi K;Ashida K;Nakazato K.
新发现本研究的中心问题是什么？在肽聚糖-多糖（PG-PS）诱导的炎症大鼠模型（PG-PS大鼠）中，牵张-缩短收缩是否能有效减轻骨骼肌萎缩和肝功能障碍？主要的调查结果及其重要性是什么？在PG-PS大鼠中，牵拉缩短收缩减轻了训练腿中的骨骼肌萎缩，并增加了循环中的白细胞介素-10。牵拉缩短收缩也可以改善PG-PS大鼠的肝功能障碍，可能是通过增加血液中的白细胞介素-10。这些发现是重要的，因为他们表明，拉伸缩短收缩是有效的，以维持肝脏功能，除了行使骨骼肌mass.AbstractStretch-shortening收缩（SSC）是一种有效的方式，以提高骨骼肌质量。然而，SSC在慢性炎症存在下的有益作用仍不清楚。在这里，我们强加了五个SSC会议单方面的小腿三头肌在年轻的雌性刘易斯大鼠。向大鼠注射溶剂或肽聚糖-多糖（PG-PS）以诱导长期炎症。PG-PS减少了双腿的腓肠肌质量，但SSC训练腿的腓肠肌质量显著大于对侧腿。即使进行SSC，PG-PS注射也会显著增加循环促炎细胞因子（如IL-1β）。在健康和炎症条件下，循环抗炎细胞因子IL-10随着SSC增加。与由等长收缩组成的对照阻力运动相比，拉伸缩短收缩还防止了由PG-PS诱导的血清天冬氨酸转氨酶活性和血浆游离苯丙氨酸浓度的增加。此外，天冬氨酸转氨酶和苯丙氨酸浓度与IL-10/IL-1β值呈显著负相关（分别为r=-0.61，P = 0.017和r =-0.66，P = 0.008）。这些结果表明，SSC训练可有效减少PG-PS诱导的肌肉萎缩和肝功能障碍，至少部分通过增加循环IL-10介导。
New FindingsWhat is the central question of this study?Is stretch–shortening contraction effective to attenuate skeletal muscle atrophy and hepatic dysfunction in a rat model of peptidoglycan–polysaccharide (PG‐PS)‐induced inflammation (PG‐PS rat)?What are the main findings and their importance?Stretch–shortening contraction attenuates skeletal muscle atrophy in the trained leg and increases circulating interleukin‐10 in PG‐PS rats. Stretch–shortening contraction also ameliorates liver dysfunction in PG‐PS rats, possibly via increased blood interleukin‐10. These findings are important because they suggest that stretch–shortening contraction is effective to maintain liver function in addition to exercised skeletal muscle mass.AbstractStretch–shortening contraction (SSC) is an effective modality to improve skeletal muscle mass. However, the beneficial effects of SSC in the presence of chronic inflammation remain unclear. Here, we imposed five SSC sessions unilaterally on the triceps surae in young female Lewis rats. Rats were injected with vehicle or peptidoglycan–polysaccharide (PG‐PS) to induce long‐lasting inflammation. The PG‐PS reduced gastrocnemius muscle mass in both legs, but that of the SSC‐trained leg was significantly greater than that of the contralateral leg. Circulating pro‐inflammatory cytokines, such as IL‐1β, were significantly increased by PG‐PS injection, even if carrying out SSC. The circulating anti‐inflammatory cytokine IL‐10 increased with SSC in both healthy and inflammatory conditions. Stretch–shortening contraction also prevented increases in serum aspartate aminotransferase activity and plasma free phenylalanine concentration induced by PG‐PS, in comparison to the control resistance exercise consisting of isometric contractions. Moreover, aspartate aminotransferase and phenylalanine concentrations demonstrated a significant and negative correlation with IL‐10/IL‐1β values (r= −0.61,P= 0.017, andr= −0.66,P= 0.008, respectively). These results suggest that SSC training is effective to reduce both muscle atrophy and the hepatic dysfunction induced by PG‐PS, mediated, at least in part, through an increase in circulating IL‐10.