Nocturnal blood pressure changes in patients with restless legs syndrome
Nocturnal blood pressure changes in patients with restless legs syndrome
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DOI：
10.1212/01.wnl.0000259036.89411.52
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发表时间：
2007-04-10
期刊：
影响因子：
9.9
通讯作者：
Lanfranchi, P. A.
中科院分区：
文献类型：
--
作者：
Pennestri, M. H.;Montplaisir, J.;Lanfranchi, P. A.
目的：评估原发性不宁腿综合征（RLS）受试者睡眠期间周期性腿部运动（PLMS）伴或不伴觉醒EEG体征相关的心率（HR）和血压（BP）变化。研究方法：10名RLS患者（4名女性，年龄47.3 ± 13.5岁）接受了一晚多导睡眠图沿着无创性逐搏血压监测。在每个受试者中分析了10个具有微觉醒的PLMS（PLMS-MA）和10个不具有微觉醒的PLMS（PLMS-noMA）。收缩压和舒张压（SBP，DBP）在25次搏动的时间窗内测量，包括每次运动开始前10次搏动和开始后15次搏动。PLMS相关的血压变化通过重复测量单因素方差分析进行评估。通过配对t检验比较PLMS-MA和PLMS-noMA相关的BP变化。Pearson相关系数用于评估心血管变化与临床和多导睡眠图变量之间的关系。结果：所有PLMS患者的血压均显著升高（平均收缩压22 mm Hg，舒张压11 mm Hg）。与PLMS-MA相关的BP变化大于与PLMS-noMA相关的BP变化（p < 0.05）。收缩压和舒张压的变化随年龄和病程的增加而增加。结论：与周期性腿部运动相关的重复夜间血压波动可能会增加不宁腿综合征患者（尤其是老年人）患心血管疾病的风险。
Objectives: To assess heart rate (HR) and blood pressure ( BP) changes associated with periodic leg movements during sleep (PLMS) with or without EEG signs of arousal in subjects with primary restless legs syndrome (RLS). Methods: Ten patients with RLS (4 women, aged 47.3 +/- 13.5 years) underwent one night of polysomnography along with noninvasive beat-to-beat BP monitoring. Ten PLMS with microarousals (PLMS-MA) and 10 PLMS without microarousals (PLMS-noMA) were analyzed in each subject. Systolic and diastolic BP (SBP, DBP) were measured within a 25-beat temporal window comprising 10 beats before and 15 beats after onset of each movement. PLMS-related BP changes were assessed by repeated measures one-way analysis of variance. BP changes associated with PLMS-MA and PLMS-noMA were compared by paired t-tests. Pearson correlation coefficients were used to assess the relationship between cardiovascular changes and clinical and polysomnographic variables. Results: BP increased significantly in association with all PLMS (on average, SBP 22 mm Hg, DBP 11 mm Hg). BP changes associated with PLMS-MA were greater vs those associated with PLMS-noMA (p < 0.05). SBP and DBP changes increased with age and the duration of illness. Conclusions: Periodic leg movements-related repetitive nocturnal blood pressure fluctuations could contribute to the risk of cardiovascular diseases in patients with restless legs syndrome, especially in the elderly.