Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study
Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study
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DOI：
10.1152/ajpendo.00574.2009
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发表时间：
2010-04-01
影响因子：
5.1
通讯作者：
Richelsen, Bjorn
中科院分区：
文献类型：
--
作者：
Christiansen, Tore;Paulsen, Soren K.;Richelsen, Bjorn
Christiansen T，Paulsen SK，Bruun JM，Pedersen SB，Richelsen B.运动训练与饮食诱导减肥对肥胖受试者代谢危险因素和炎症标志物的影响：一项为期12周的随机干预研究Am J Physiol Endocrinol Metab 298：E824-E831，2010年。首次发表于2010年1月13日; doi：10.1152/ajpendo.00574.2009.-本研究的目的是调查运动训练和饮食诱导的体重减轻单独或联合对肥胖受试者的循环，脂肪组织（AT）和骨骼肌（SM）中的炎症标志物的影响。79名肥胖受试者被随机分配到12周的干预组：1）仅运动（EXO），2）使用极低能量饮食（DIO）的饮食诱导减肥，3）运动和饮食诱导减肥联合（DEX）。在基线和12周后收集血液样本（代谢和炎症标志物）和AT和SM活检（mRNA表达）。EXO组体重减轻3.5 kg，DIO和DEX组体重减轻12 kg。EXO和DEX组的Vo（2 max）增加了14-18%，DIO组无变化。在DIO和DEX组中，MCP-1、MIP-1 α、IL-15和IL-18的循环水平降低，脂联素升高（均P < 0.05）。在EXO组中，MCP-1降低了10%（P = 0.06）。通过结合所有三组的体重减轻，我们发现体重减轻程度与几种炎症标志物的改善之间存在相关性（P < 0.05）。在AT活检中，DIO和DEX组的受试者对炎症标志物的基因表达普遍有益但无显著影响。EXO组除脂联素表达增加外，AT脂肪因子mRNA表达无明显变化（P> 0.05）。SM组IL-6基因表达均较正常对照组增加（P < 0.05）。总之，发现相当大的体重减轻（>5-7%）对这些肥胖受试者中的循环炎性标志物具有有益作用。有氧运动12周，增加（V）超过doto（2 max），发现对这些肥胖患者的循环炎症标志物没有影响。这表明，更密集的运动可能是必要的，以影响全身炎症。
Christiansen T, Paulsen SK, Bruun JM, Pedersen SB, Richelsen B. Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study. Am J Physiol Endocrinol Metab 298: E824-E831, 2010. First published January 13, 2010; doi:10.1152/ajpendo.00574.2009.-The purpose of this study was to investigate the effect of exercise training and diet-induced weight loss alone or in combination on inflammatory markers in circulation, in adipose tissue (AT) and in skeletal muscle (SM) in obese subjects. Seventy-nine obese subjects were randomized into a 12-wk intervention: 1) exercise only (EXO), 2) diet-induced weight loss using a very low energy diet (DIO), and 3) exercise and diet-induced weight-loss combined (DEX). Blood samples ( metabolic and inflammatory markers) and AT and SM biopsies ( mRNA expression) were collected at baseline and after 12 wk. In the EXO group the weight loss was 3.5 kg and in the DIO and DEX groups it was 12 kg in both. Vo(2max) was increased by 14-18% in the EXO and DEX groups with no changes in the DIO group. In the DIO and DEX groups, circulating levels of MCP-1, MIP-1 alpha, IL-15, and IL-18 were decreased, and adiponectin was increased (P < 0.05 for all). In the EXO group, MCP-1 was decreased with 10% (P = 0.06). By combining the weight loss in all three groups, we found a correlation between the degree of weight loss and improvement in several of the inflammatory markers (P < 0.05). In AT biopsies, subjects in the DIO and DEX groups achieved a general beneficial but nonsignificant effect on the gene expression of inflammatory markers. In the EXO group, no changes in AT adipokine mRNA were found except for an increment of adiponectin (P < 0.05). In SM, the only observed change was that the gene expression of IL-6 was increased in all three groups (P < 0.05). In conclusion, rather large weight losses (>5-7%) were found to have beneficial effects on circulating inflammatory markers in these obese subjects. Aerobic exercise for 12 wk, which increased (V) over doto(2max), was found to have no effects on circulating inflammatory markers in these obese patients. It is suggested that more intensive exercise may be necessary to affect systemic inflammation.