Pulmonary immunity and extracellular matrix interactions.
Pulmonary immunity and extracellular matrix interactions.
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DOI：
10.1016/j.matbio.2018.04.003
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发表时间：
2018-04
期刊：
影响因子：
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通讯作者：
D. O’Dwyer;S. Gurczynski;B. Moore
中科院分区：
文献类型：
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作者：
D. O’Dwyer;S. Gurczynski;B. Moore
肺部有一个复杂的免疫系统，由先天免疫细胞和获得性免疫细胞组成。肺固有免疫细胞上受体对感染和损伤的识别对于获得性免疫细胞产生抗原特异性反应至关重要。肺的细胞外基质由间质和基底膜组成，在这些免疫系统的调节中起着关键作用。基质由数百种组装的蛋白质组成，这些蛋白质相互作用形成生物活性支架。这种被酶修饰的模板可以促进细胞的功能和分化，并随着年龄和肺部疾病的变化而动态变化。在这里，我们探索先天免疫和获得性免疫与肺细胞外基质之间的关系。我们讨论了细胞外基质蛋白之间的相互作用，包括糖胺多聚糖，对天然免疫信号效应器，如Toll样受体的显著影响。我们描述了细胞外基质蛋白与获得性免疫和白细胞迁移到肺内损伤部位的关系。对这些相互作用的进一步研究将有助于更多地了解基质生物学在肺免疫中的作用。急慢性肺部疾病新疗法的开发依赖于对这些复杂的基质-免疫相互作用的全面了解。
The lung harbors a complex immune system composed of both innate and adaptive immune cells. Recognition of infection and injury by receptors on lung innate immune cells is crucial for generation of antigen-specific responses by adaptive immune cells. The extracellular matrix of the lung, comprising the interstitium and basement membrane, plays a key role in the regulation of these immune systems. The matrix consists of several hundred assembled proteins that interact to form a bioactive scaffold. This template, modified by enzymes, acts to facilitate cell function and differentiation and changes dynamically with age and lung disease. Herein, we explore relationships between innate and adaptive immunity and the lung extracellular matrix. We discuss the interactions between extracellular matrix proteins, including glycosaminoglycans, with prominent effects on innate immune signaling effectors such as toll-like receptors. We describe the relationship of extracellular matrix proteins with adaptive immunity and leukocyte migration to sites of injury within the lung. Further study of these interactions will lead to greater knowledge of the role of matrix biology in lung immunity. The development of novel therapies for acute and chronic lung disease is dependent on a comprehensive understanding of these complex matrix-immunity interactions.