Prostaglandin E-major urinary metabolite versus fecal immunochemical occult blood test as a biomarker for patient with ulcerative colitis
Prostaglandin E-major urinary metabolite versus fecal immunochemical occult blood test as a biomarker for patient with ulcerative colitis
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DOI：
10.1186/s12876-020-01256-5
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发表时间：
2020-04-19
影响因子：
2.4
通讯作者：
Sugimoto, Ken
中科院分区：
文献类型：
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作者：
Ishida, Natsuki;Miyazu, Takahiro;Sugimoto, Ken
研究背景前列腺素E-主要尿代谢产物（PGE-MUM）可能是评价溃疡性结肠炎（UC）疾病活动性的一种新的生物标志物。我们比较了它的有用性，粪便免疫化学潜血试验（FIT）。MethodsPGE-MUM和FIT测量92尿和粪便标本从60例UC患者进行。结果PGE-MUM水平和FIT结果与eMayo评分有显著相关性（P< 0.001和P < 0.001），而与EMayo评分无显著相关性（P> 0.05）。
BackgroundProstaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blood test (FIT).MethodsPGE-MUM and FIT measurements were performed of 92 urinary and fecal samples obtained from 60 patients with UC. Endoscopic activity was determined by Mayo endoscopic subscore (eMayo) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score.ResultsPGE-MUM levels and FIT results showed a significant correlation with respect to eMayo (P< 0.001 and P