Tailoring the Shape and Size of Artificial Cells
Tailoring the Shape and Size of Artificial Cells
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DOI：
10.1021/acsnano.9b05112
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发表时间：
2019-07-01
期刊：
影响因子：
17.1
通讯作者：
Devaraj, Neal K.
中科院分区：
文献类型：
--
作者：
Bhattacharya, Ahanjit;Devaraj, Neal K.
活细胞通过复杂的生化机制实现对形状和大小的精确控制。然而，这种精确度在人工细胞区室中模拟是极其具有挑战性的。到目前为止，已经采用了各种物理化学和机械干预来调整模型系统的尺寸，如脂质体，乳液，凝聚体和聚合物胶囊。在这个角度来看，我们讨论了人工细胞研究中控制形状和大小的最新技术以及需要解决的挑战。
Living cells achieve precise control of shape and size through sophisticated biochemical machinery. However, such precision is extremely challenging to emulate in artificial cellular compartments. So far, various physicochemical and mechanical interventions have been employed to tailor the dimensions of model systems such as liposomes, emulsions, coacervates, and polymer capsules. In this Perspective, we discuss the state of the art in artificial cell research in controlling shape and size and the challenges that need to be addressed.