Interaction between effects of stress and morphine on body temperature in rats.
Interaction between effects of stress and morphine on body temperature in rats.
复制标题
压力和吗啡对大鼠体温影响之间的相互作用。
DOI：
10.1016/0024-3205(81)90750-5
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发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
R. Eikelboom
中科院分区：
文献类型：
--
作者：
J. Stewart;R. Eikelboom
在大鼠中检查了应激诱导的体温变化与吗啡诱导的体温变化之间的关系。三组8只动物完全习惯于处理和直肠探测，三组8只实验幼稚动物腹膜内注射1，5或30 mg/kg硫酸吗啡，连续6天。与注射前基线相比，温度读数的差异表明，在实验第1天，应激有效地增加了吗啡的效力，导致最低剂量下体温升高略有增加，最高剂量下体温降低大大增加。因此，对于习惯的动物，吗啡的剂量-反应曲线向右移动。到第6天，在重复注射吗啡后，所有动物均显示对吗啡的体温过高反应，习惯和非习惯动物之间的差异消失。这些研究结果进行了讨论的内源性阿片类药物在应激动物和外源性吗啡的作用产生的温度变化之间的相互作用。
The relation between stress-induced and morphine-induced body temperature changes was examined in rats. Three groups of eight animals thoroughly habituated to handling and rectal probing, and three groups of eight experimentally naive animals were injected intraperitoneally with either 1, 5, or 30 mg/kg morphine sulphate on each of six consecutive days. Differences in temperature readings from the pre-injection baseline showed that on Day 1 of the experiment stress acted to effectively increase the potency of morphine, causing slightly increased hyperthermia at the lowest dose and greatly increased hypothermia at the highest dose. Thus for habituated animals the dose-response curve for morphine was shifted to the right. By Day 6, after repeated morphine injections, all animals showed a hyperthermic response to morphine and the differences between habituated and unhabituated animals had disappeared. These findings were discussed in terms of the interaction between the temperature changes produced by endogenous opioids in stressed animals and the actions of exogenously administered morphine.