Cellular and extracellular siderophores of Aspergillus nidulans and Penicillium chrysogenum.
Cellular and extracellular siderophores of Aspergillus nidulans and Penicillium chrysogenum.
复制标题
构巢曲霉和产黄青霉的细胞和细胞外铁载体。
DOI：
10.1128/mcb.1.2.94-100.1981
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发表时间：
1981
影响因子：
5.3
通讯作者：
Horowitz,RM
中科院分区：
文献类型：
--
作者：
Charlang,G;Ng,B;Horowitz,NH;Horowitz,RM
除了众所周知的培养基铁载体之外，构巢曲霉和产黄青霉还产生特定的细胞铁载体。由于先前在粗糙脉孢菌中发现了这一点，因此对于丝状子囊菌来说可能普遍如此。 A. 细胞铁载体构巢菌铁红素； P 的那个。铁铬黄Nidulans还含有三乙酰融合剂，一种没有明显生物活性的铁载体。两种物种的分生孢子在高盐浓度下都会失去铁载体并变得依赖于铁载体。 N 中也发现了这一点。 crassa，其中水分活度降低已被证明是原因。我们使用基于这种依赖性的测定程序来重新检查这些物种的细胞外铁载体。在菌丝快速生长过程中，A.尼杜兰桑 P. chrysogenum 产生两种高活性、未鉴定的铁载体，随后被活性较低或无活性的产物（就 P 而言）所取代。 chrysogenum和三乙酰融合剂在A的情况下。构巢菌仅粗分泌粪便。真菌铁载体代谢多种多样且复杂。
Aspergillus nidulansandPenicillium chrysogenumproduce specific cellular siderophores in addition to the well-known siderophores of the culture medium. Since this was found previously inNeurospora crassa, it is probably generally true for filamentous ascomycetes. The cellular siderophore ofA. nidulansis ferricrocin; that ofP. chrysogenumis ferrichrome.A. nidulansalso contains triacetylfusigen, a siderophore without apparent biological activity. Conidia of both species lose siderophores at high salt concentrations and become siderophore dependent. This has also been found inN. crassa, where lowering of the water activity has been shown to be the causal factor. We used an assay procedure based on this dependency to reexamine the extracellular siderophores of these species. During rapid mycelial growth, bothA. nidulansandP. chrysogenumproduced two highly active, unidentified siderophores which were later replaced by a less active or inactive product—coprogen in the case ofP. chrysogenumand triacetylfusigen in the case ofA. nidulans.N. crassasecreted coprogen only. Fungal siderophore metabolism is varied and complex.