Reduction of right medial pulvinar volume and neuron number in schizophrenia
Reduction of right medial pulvinar volume and neuron number in schizophrenia
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DOI：
10.1016/j.schres.2006.10.006
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发表时间：
2007-02-01
影响因子：
4.5
通讯作者：
Yiannoulos, Georgia
中科院分区：
文献类型：
--
作者：
Byne, William;Fernandes, Jason;Yiannoulos, Georgia
一些研究已经描述了精神分裂症(SZ)患者枕骨体积和/或神经元数量的减少。为了更好地定位这些变化，我们评估了慢性SZ受试者和无精神病史受试者的枕骨及其几个分支的体积和神经元数量。SZ组枕骨总体积和神经元数量明显减少，仅内侧部差异有显着性。内侧枕连接不同的异交感皮质区域，提示这些缺陷可能是精神分裂症特征的高级综合功能异常的原因之一。(C)2006爱思唯尔B.V.保留所有权利。
Several studies have described a reduction of pulvinar volume and/or neuronal number in schizophrenia (SZ). In order to better localize these changes, we assessed volume and neuronal number of the pulvinar and several of its subdivisions in postmortem material from subjects with chronic SZ and subjects with no psychiatric history. Total pulvinar volume and neuronal number were significantly lower in SZ and these differences were significant in only in its medial division. The medial pulvinar interconnects various heteromodal cortical regions suggesting that these deficits may contribute to the abnormalities of higher order integrative functions characteristic of schizophrenia. (c) 2006 Elsevier B.V. All rights reserved.