Risk factors in hepatitis C virus‐infected blood donors
Risk factors in hepatitis C virus‐infected blood donors
复制标题
丙型肝炎病毒感染献血者的危险因素
DOI：
10.1046/j.1537-2995.1991.31892023508.x
复制
发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
P. Lelie
中科院分区：
文献类型：
--
作者：
C. Poel;H. Cuypers;H. Reesink;Q. Choo;G. Kuo;J. Han;Stella Quan;AlanJ. Polito;J. Verstraten;J. Wouw;W. Schaasberg;Michael Houghton;P. Lelie
在荷兰125名酶联免疫吸附试验（ELISA）抗HCV阳性的献血者中研究了肠外和非肠外暴露于丙型肝炎病毒（HCV）感染的风险因素。风险因素与四抗原重组免疫印迹试验（4-RIBA）和HCV 5′非翻译区聚合酶链反应（PCR）的确证性检测结果相关。125例抗HCV C100 ELISA阳性献血者中有12例（10%）为4-RIBA阳性。12名4-RIBA阳性献血者中有11名（92%）为PCR阳性，其余113名4-RIBA阴性或不确定的献血者均为PCR阴性。12名4-RIBA阳性献血者中有11名（92%）存在胃肠外暴露的风险因素，而113名4-RIBA阴性或不确定的献血者中有17名（15%）存在胃肠外暴露的风险因素。经计算，阿姆斯特丹献血者中确诊的HCV感染的患病率为0.04%;胃肠外暴露似乎是HCV感染的主要危险因素。
Risk factors of parenteral and nonparenteral exposure to hepatitis C virus (HCV) infection were studied in 125 blood donors in The Netherlands who were positive for anti‐HCV on enzyme‐linked immunosorbent assay (ELISA). Risk factors were related to confirmatory test results of four‐antigen recombinant immunoblot assay (4‐RIBA) and polymerase chain reaction (PCR) of the HCV 5′ untranslated region. Twelve (10%) of the 125 anti‐HCV C100 ELISA‐positive blood donors were 4‐RIBA positive. Eleven (92%) of 12 4‐RIBA‐positive blood donors were PCR positive, and all 113 remaining 4‐RIBA‐negative or ‐indeterminate donors were PCR negative. Eleven (92%) of 12 4‐RIBA‐positive blood donors had a risk factor of parenteral exposure, as compared to 17 (15%) of 113 4‐RIBA‐negative or ‐indeterminate donors. The prevalence of confirmed HCV infection among Amsterdam blood donors is calculated at 0.04 percent; parenteral exposure appears to be the major risk factor for HCV infection.