EVIDENCE FOR DECREASED ENDOGENOUS DOPAMINE AND OPIOID INHIBITORY INFLUENCES ON LH-SECRETION IN POLYCYSTIC OVARY SYNDROME
EVIDENCE FOR DECREASED ENDOGENOUS DOPAMINE AND OPIOID INHIBITORY INFLUENCES ON LH-SECRETION IN POLYCYSTIC OVARY SYNDROME
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DOI：
10.1111/j.1365-2265.1984.tb00114.x
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发表时间：
1984-01-01
影响因子：
3.2
通讯作者：
YEN, SSC
中科院分区：
文献类型：
--
作者：
CUMMING, DC;REID, RL;YEN, SSC
探讨多囊卵巢综合征（PCO）患者多巴胺能和阿片能机制对促黄体生成素（LH）分泌的抑制作用。阿片类受体拮抗剂纳洛酮、多巴胺受体拮抗剂甲氧氯普胺或人合成的h-内啡肽均不能改变PCO患者的LH分泌活性。由于相同剂量的这些拮抗剂和阿片激动剂分别引起正常周期女性LH水平的上升和下降，这些研究结果表明，内源性多巴胺和阿片控制缺陷的潜在下丘脑成分可能是该综合征中促性腺激素分泌不当的原因。
The inhibitory role of the dopaminergic and opioidergic mechanisms in the control of LH [luteinizing hormone] secretion in patients with polycystic ovary syndrome (PCO) was evaluated. The administration of an opiate receptor antagonist, naloxone, of a dopamine receptor antagonist, metoclopramide, or of human synthetic bh-endorphin, were unable to alter LH secretory activity in patients with PCO. Since identical doses of these antagonists and the opiate agonist have elicited, respectively, a rise and fall of LH levels in normal cycling women, these findings suggest that an underlying hypothalamic component of defect in endogenous dopamine and opioid control may be responsible for the inappropriate gonadotropin secretion in this syndrome.