Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs
Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs
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DOI：
10.1007/s11259-011-9466-x
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发表时间：
2011-04-01
影响因子：
2.2
通讯作者：
Arai, Toshiro
中科院分区：
文献类型：
--
作者：
Mori, Nobuko;Lee, Peter;Arai, Toshiro
在狗身上，肥胖的一个常见迹象是高脂血症，其特征是高胆固醇血症和/或高甘油三酯血症。高脂血症可由循环脂蛋白(LP)的数量增加或不同LP类别中较高的脂质浓度引起。在这项研究中，我们试图确定肥胖狗的胆固醇脂蛋白谱，特别是亚高密度脂蛋白-胆固醇百分比是否发生异常。使用临床健康和无疾病(无明显体征)的肥胖犬的身体状况评分，我们试图确定年龄、性别和肥胖状况对胆固醇脂蛋白谱的影响。总体而言，在8岁的肥胖狗中没有观察到图案上的异常。然而，在年龄较大的肥胖动物(8岁年龄千分之几)中，观察到的胆固醇脂蛋白总体异常模式是HDL2和3%显著降低，同时HDL1-CHO或VLDL-CHO和LDLCHO%相应增加，这取决于性别。线性回归分析显示肥胖状况对总胆固醇、高密度脂蛋白胆固醇和3-胆固醇、极低密度脂蛋白和低密度脂蛋白-胆固醇水平有显著影响(P值分别为0.02、0.046和0.045)，而与高密度脂蛋白-胆固醇水平关系不大(P=0.062)。另一方面，年龄显著影响甘油三酯、总胆固醇和高密度脂蛋白胆固醇水平(P=0.009、0.006和0.002)，而性别影响极低密度脂蛋白和低密度脂蛋白胆固醇水平(P=0.024)。因此，结合BCS，胆固醇脂蛋白图谱的异常可能对肥胖状态的评估和诊断有潜在的作用，特别是对于可能被认为是临界性肥胖的老年超重动物。
A common sign of obesity, in dogs, is hyperlipidemia, which is characterized by hypercholesterolemia and/or hypertriglycemia. Hyperlipidemia can be caused by a quantitative increase in circulating lipoproteins (LP) or by a higher lipid concentration in the various LP classes. In this study, we sought to determine whether aberrations occur with cholesterol lipoprotein profile, especially with sub HDL-cholesterol fraction % in obese dogs. Using clinically healthy and disease free (no overt signs) body condition score classified obese dogs, of all ages, we attempted to determine the influence of age, gender and obesity status on cholesterol lipoprotein profiling. Overall, no aberration in pattern was observed in obese dogs < 8 years of age. However, in older obese animals (a parts per thousand yen8 years of age), the general aberration pattern to cholesterol lipoprotein observed was that a significant decrease in HDL2 and 3 fraction % occurs with a concomitant increase in either HDL1-Cho or VLDL and LDL -Cho fraction % depending on gender. Linear regression analysis indicated that obesity status appears to significantly affect total cholesterol, HDL2 and 3-Cho, VLDL and LDL-Cho levels (P = 0.02, 0.046, and 0.045, respectively), whereas it is borderline with HDL1-Cho (P = 0.062). On the other hand, age significantly influenced TG, Total cholesterol, and HDL1-Cho levels (P = 0.009, 0.006, and 0.002, respectively), while gender influenced VLDL and LDL-Cho (P = 0.024) level. Therefore, aberrations in cholesterol lipoprotein profile pattern might be of potential use to assess and diagnose obesity status, in conjunction with BCS, especially of older overweight animals which might be considered borderline obese.