Testing the model of caudo-rostral organization of cognitive control in the human with frontal lesions
Testing the model of caudo-rostral organization of cognitive control in the human with frontal lesions
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DOI：
10.1016/j.neuroimage.2013.09.031
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发表时间：
2014-01-01
期刊：
影响因子：
5.7
通讯作者：
Levy, R.
中科院分区：
文献类型：
--
作者：
Azuar, C.;Reyes, P.;Levy, R.
认知控制的级联模型主要依赖于功能性神经影像学研究，它规定了侧面额叶皮层（LFC）的组织为涉及三个级别的认知控制的级联，并在从较前的LFC区域到前额叶前额叶前额叶前额叶前额外的前额外前额叶进行了三个级别的认知控制。地区。本实验在LFC病变患者中测试了该模型，并研究了沿Caudo-Rostral轴的执行功能的层次结构，即不同LFC区域在控制行为中的各自作用。在32例局灶性LFC病变的患者中进行了基于体素的病变映射和感兴趣的区域分析，这些患者执行了评估级联模型的认知任务。我们首先表明，沿尾尾轴的三个不同的LFC区域都承受了三个不同的控制水平，它们对于自适应行为是必不可少的。其次，我们发现前额叶认知控制具有一个不对称的组织：涉及更高前额叶区域的较高控制过程依赖于更后方区域中较低控制过程的完整性，而较低的控制过程可以运行，无论较高控制过程的完整性如何。总的来说，这些发现支持了从前前部到前额叶区域的执行程序的尾声级联。 （c）2013 Elsevier Inc.保留所有权利。
The cascade model of cognitive control, mostly relying on functional neuroimaging studies, stipulates that the lateral frontal cortex (LFC) is organized as a cascade of executive processes involving three levels of cognitive control, implemented in distinct LFC areas from the premotor to the anterior prefrontal regions. The present experiment tested this model in patients with LFC lesions and studied the hierarchy of executive functions along the caudo-rostral axis, i.e. the respective roles of the different LFC areas in the control of behavior. Voxel-based lesionsymptom mapping and region of interest group analyses were conducted in 32 patients with focal LFC lesions who performed cognitive tasks assessing the cascade model. We first showed that three different LFC areas along the caudo-rostral axis subserved three distinct control levels, whose integrity is necessary for adaptive behavior. Second, we found that prefrontal cognitive control has an asymmetric organization: higher control processes involving more anterior prefrontal regions rely on the integrity of lower control processes in more posterior regions, while lower control processes can operate irrespective of the integrity of higher control processes. Altogether, these findings support a caudo-rostral cascade of executive processes from premotor to anterior prefrontal regions. (C) 2013 Elsevier Inc. All rights reserved.