Relationship of continuous glucose monitoring-related metrics with HbA1c and residual β-cell function in Japanese patients with type 1 diabetes.
Relationship of continuous glucose monitoring-related metrics with HbA1c and residual β-cell function in Japanese patients with type 1 diabetes.
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DOI：
10.1038/s41598-021-83599-x
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发表时间：
2021-02-17
影响因子：
4.6
通讯作者：
Ikegami H
中科院分区：
文献类型：
--
作者：
Babaya N;Noso S;Hiromine Y;Taketomo Y;Niwano F;Yoshida S;Yasutake S;Kawabata Y;Ikegami H
最近制定了连续血糖监测(CGM)衍生指标的目标；然而，对长期稳定血糖控制的CGM数据的研究有限。我们分析了19名日本成年1型糖尿病患者的194,279个CGM值。分析了在四个月的稳定血糖控制期间获得的CGM数据。从基线计算不同持续时间内(120、90、60、30和7天内)的CGM相关指标。范围内时间(TIR；葡萄糖70-180m g/dL)、范围以上时间(TAR；葡萄糖 ≥ 181m g/dL)和平均血糖水平，但不在范围内时间(tbr；葡萄糖 ≤ 69m g/dL)与糖化血红蛋白(HbA1c)值密切相关(P <； 0.0001)。总胆红素与血糖变异系数(CV)相关(P <； )。空腹血清C肽水平与血糖变异系数呈负相关(P <； 0.01)。糖化血红蛋白约为7%，相当于74%的TIR和20%的焦油。CGM周期越短，HbA1c与CGM相关指标的关系越弱。TIR、TAR和平均血糖水平准确地反映了血糖控制稳定的日本1型糖尿病患者的HbA1c值。葡萄糖变异系数和总胆红素测定补充了糖化血红蛋白检测血糖变异性和低血糖的局限性。稳定的血糖控制和最小的低血糖依赖于残留的β细胞功能。
The targets for continuous glucose monitoring (CGM)-derived metrics were recently set; however, studies on CGM data over a long period with stable glycemic control are limited. We analyzed 194,279 CGM values obtained from 19 adult Japanese patients with type 1 diabetes. CGM data obtained during stable glycemic control over four months were analyzed. CGM-related metrics of different durations “within 120, 90, 60, 30, and 7 days” were calculated from baseline. Time in range (TIR; glucose 70–180 mg/dL), time above range (TAR; glucose ≥ 181 mg/dL), and average glucose levels, but not time below range (TBR; glucose ≤ 69 mg/dL), strongly correlated with glycated hemoglobin (HbA1c) values (P < 0.0001). TBR correlated with glucose coefficient of variation (CV) (P < 0.01). Fasting serum C-peptide levels negatively correlated with glucose CV (P < 0.01). HbA1c of approximately 7% corresponded to TIR of 74% and TAR of 20%. The shorter the CGM period, the weaker was the relationship between HbA1c and CGM-related metrics. TIR, TAR, and average glucose levels accurately reflected HbA1c values in Japanese patients with type 1 diabetes with stable glycemic control. Glucose CV and TBR complemented the limitation of HbA1c to detect glucose variability and hypoglycemia. Stable glycemic control with minimal hypoglycemia depended on residual β-cell function.
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影响因子：
7.7
作者：
Keenan HA;Sun JK;Levine J;Doria A;Aiello LP;Eisenbarth G;Bonner-Weir S;King GL
通讯作者：
King GL
影响因子：
39.2
作者：
Bergenstal, Richard M.;Gal, Robin L.;Beck, Roy W.
通讯作者：
Beck, Roy W.
影响因子：
7.7
作者：
FUKUDA, M;TANAKA, A;SHIMA, K
通讯作者：
SHIMA, K
影响因子：
16.2
作者：
Riddle, Matthew C.;Gerstein, Hertzel C.;Cefalu, William T.
通讯作者：
Cefalu, William T.
影响因子：
8.2
作者：
Gibb, Fraser W.;McKnight, John A.;Strachan, Mark W. J.
通讯作者：
Strachan, Mark W. J.