A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients.
A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients.
复制标题
DOI：
10.1016/j.bbagen.2006.12.013
复制
发表时间：
2007-06
期刊：
影响因子：
--
通讯作者：
W. Stein;T. Litman;T. Fojo;S. Bates
中科院分区：
文献类型：
--
作者：
W. Stein;T. Litman;T. Fojo;S. Bates
一个公开的微阵列基因表达数据库，包含174个肿瘤样本的数据，从10个组织进行挖掘，使识别类基因的表达显着相关的棘手性，或易处理性，从这样的组织来源的肿瘤的治疗。作为一个衡量指标的易处理性，5年生存的患者提出了远处（转移）肿瘤。编码与细胞粘附相关的蛋白质和参与代谢氧化或还原的酶的基因在难治性癌症中上调。编码与DNA转录控制有关的蛋白质的基因在难治性癌症中下调。我们描述了关于细胞功能的假设，这些假设可能有助于设计新的治疗方式，旨在提高癌症患者的生存率。
A published microarray gene expression database containing data on 174 tumor samples from ten tissues was mined, enabling the identification of classes of genes whose expression correlates significantly with the intractability, or tractability, to therapy of tumors derived from such tissues. As a measure of tractability, the 5-year survival of patients presenting with distant (metastatic) tumors was used. Genes that encode proteins related to cell adhesion, and enzymes involved in metabolic oxidation or reduction, were upregulated in intractable cancers. Genes that encode proteins implicated in the control of DNA transcription were downregulated in the intractable cancers. We describe hypotheses with regard to cell functions that may help in designing new therapeutic modalities, aimed at improving survival of cancer patients.