Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging
Rational design of water-dispersible and biocompatible nanoprobes with H2S-triggered NIR emission for cancer cell imaging
复制标题
用于癌细胞成像的具有 H2S 触发近红外发射的水分散性和生物相容性纳米探针的合理设计
DOI：
10.1039/d0tb00173b
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发表时间：
2020-07-28
影响因子：
7
通讯作者：
Gu, Xianfeng
中科院分区：
文献类型：
--
作者：
Liu, Hengyan;Xu, Ge;Gu, Xianfeng
我们提出了一种通过将小分子探针包裹在表面交联胶束(SCM)的疏水内部来构建H_2S特异性纳米探针的方法，使所设计的纳米探针具有良好的水溶性和生物相容性。重要的是，所获得的纳米探针在比率荧光和发光近红外发射模式下都表现出对硫化氢的良好响应，从而能够准确地识别富含硫化氢的结直肠癌细胞。
We present an approach for constructing a H2S-specific nanoprobe by the entrapment of a small molecule probe within the hydrophobic interior of surface cross-linked micelles (SCMs), endowing the designed nanoprobes with good water solubility and biocompatibility. Importantly, the obtained nanoprobes displayed good responsiveness to H2S in both ratiometric fluorescence and light-up NIR emission modes, thus enabling accurate identification of H2S-rich colorectal cancer cells.