Possible involvement of Hcn1 ion channel in learning and memory dysfunction in SAMP8 mice
Possible involvement of Hcn1 ion channel in learning and memory dysfunction in SAMP8 mice
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DOI：
10.1016/j.bbrc.2013.09.145
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发表时间：
2013-11-08
影响因子：
3.1
通讯作者：
Isobe, Masaharu
中科院分区：
文献类型：
--
作者：
Akbor, Maruf Mohammad;Tomobe, Koji;Isobe, Masaharu
衰老加速小鼠倾向8（SAMP 8）品系在2月龄时表现出年龄相关的学习和记忆缺陷（LMD）。对264只F2杂交SAMP 8 x JF 1小鼠的联合连锁分析和RNA-seq分析在13号染色体LMD区域的29个基因中鉴定出Hall基因。与日本花式小鼠1（JF 1）相比，SAMP 8品系中的Hcn 1显示出低15倍的多聚谷氨酰胺重复。全细胞膜片钳分析显示，Hcn 1离子电导率在SAMP 8中显著低于JF 1，这可能与学习和记忆缺陷有关。(C)2013 Elsevier Inc. All rights reserved.
The senescence-accelerated mouse prone 8 (SAMP8) strain exhibits age-related learning and memory deficits (LMD) at 2 months of age. Combined linkage analysis of 264 F2 intercross SAMP8 x JF1 mice and RNA-seq analysis identified Hall gene out of 29 genes in the LMD region on chromosome 13. Hcn1 in SAMP8 strain showed 15 times less polyglutamine repetition compared to Japanese fancy mouse 1 (JF1). Whole cell patch clamp analysis showed that Hcn1 ion conductivity was significantly lower in SAMP8 compared to that of JF1, which may be associated with learning and memory deficiency. (C) 2013 Elsevier Inc. All rights reserved.