Transgenic mice expressing Alzheimer amyloid precursor proteins
Transgenic mice expressing Alzheimer amyloid precursor proteins
复制标题
DOI：
10.1016/s0531-5565(98)00045-x
复制
发表时间：
1998-11-01
影响因子：
3.9
通讯作者：
Hsiao, K
中科院分区：
文献类型：
--
作者：
Hsiao, K
在阿尔茨海默氏淀粉样前体蛋白（APP）基因鉴定近十年后，几组研究人员已经创建了表达APP的转基因小鼠，其模拟阿尔茨海默氏病的一些突出的行为和病理特征（Quon et al.，1991; Games等人，1995; Hsiao等人，1995，1996; Moechars等人，1996; Sturchler-Pierrat等人，1997年）。这些特征在不同系的小鼠中不同程度地存在，包括与年龄相关的学习和记忆障碍、神经元丢失、神经胶质增生、神经炎变化、淀粉样蛋白沉积和异常tau磷酸化。没有小鼠模型表现出阿尔茨海默病的每一个神经病理学特征存在。是否需要精确模拟阿尔茨海默病的神经病理学来了解阿尔茨海默病的神经功能障碍尚不清楚。本文综述了阿尔茨海默病的各种小鼠模型。(C)1998年爱思唯尔科学公司
Nearly a decade after the identification of the Alzheimer amyloid precursor protein (APP) gene several groups of investigators have created transgenic mice expressing APP that simulate some of the prominent behavioral and pathological features of Alzheimer's disease (Quon et al., 1991; Games et al., 1995; Hsiao et al., 1995, 1996; Moechars er al., 1996; Sturchler-Pierrat ct al., 1997). These features, which are present to various degrees in different lines of mice, include age-related impairment in learning and memory, neuronal loss, gliosis, neuritic changes, amyloid deposition, and abnormal tau phosphorylation. No mouse model exhibiting every neuropathological feature of Alzheimer's disease exists. Whether an exact simulation of Alzheimer neuropathology is required to understand neural dysfunction in Alzheimer's disease is unclear. Various mouse models of Alzheimer's disease are summarized in this article. (C) 1998 Elsevier Science Inc.