Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial
Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial
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DOI：
10.1007/s13340-021-00524-3
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发表时间：
2021-07-18
影响因子：
2.2
通讯作者：
Ito, Sadayoshi
中科院分区：
文献类型：
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作者：
Ogawa, Susumu;Ohsaki, Yusuke;Ito, Sadayoshi
导言富氢电解水(EHW)对氧化应激(OS)有抑制作用。然而，它对2型糖尿病(T2 DM)的益处仍不清楚。本研究旨在探讨EHW对2型糖尿病的影响。方法采用多中心、前瞻性、双盲、随机对照试验，将50例2型糖尿病患者分为EHW组和FW组。主要终点是使用胰岛素抵抗稳态模型评估(HOMA-IR)评估胰岛素抵抗(IR)的变化。观察两组患者尿8-羟基-2‘-脱氧鸟苷排泄量(8-OHdG)、血浆双离体氧代谢产物(d-ROM)、血浆生物抗氧化能力(BAP)及血乳酸浓度等临床指标。结果EHW组和FW组HOMA-IR变化差异无统计学意义。然而，EHW组的乳酸水平显著下降，而且这种下降与HOMA-IR、空腹血糖和空腹血浆胰岛素水平的下降显著相关。在患有HOMA-IR和GT；1.73的EHW受试者中，血清乳酸水平也与90分钟后胰岛素推注分泌减少和葡萄糖负荷显著相关。未观察到EHW治疗相关不良反应。结论EHW对2型糖尿病患者HOMA-IR的影响不明显，需要更大规模和更长期的研究来验证EHW对T2 DM患者的影响。
Introduction Electrolyzed hydrogen-rich water (EHW) is known to have suppressive effects on oxidative stress (OS). However, its benefit in type 2 diabetes mellitus (T2DM) remains unclear. This study aimed to investigate the effect of EHW on T2DM. Methods This was a multicenter, prospective, double-blind, randomized controlled trial of 50 patients with T2DM who were assigned to the EHW or filtered water (FW) groups. The primary endpoint was changes in insulin resistance (IR) evaluated using the homeostasis model assessment of insulin resistance (HOMA-IR). OS markers such as urinary 8-hydroxy-2 '-deoxyguanosine excretion (8-OHdG), plasma diacron-reactive oxygen metabolites (d-ROM), and plasma biological antioxidant potential (BAP) and other clinical data, including serum lactate concentration (lactate), were evaluated. Results There were no significant differences in the changes in HOMA-IR between the EHW and FW groups. However, lactate levels decreased significantly in the EHW group, and this decrease was significantly correlated with a reduction in HOMA-IR, fasting plasma glucose, and fasting plasma insulin level. Serum lactate level also significantly correlated to decreased insulin bolus secretion after 90 min with glucose loading in the EHW subjects with HOMA-IR > 1.73. No EHW treatment-related adverse effects were observed. Conclusion There were no significant effect of EHW in the change in HOMA-IR in this study; larger-scale and longer-term study are needed to verify the effects of EHW in T2DM patients.