Effect of early onset angiotensin converting enzyme inhibition on myocardial capillaries.
Effect of early onset angiotensin converting enzyme inhibition on myocardial capillaries.
复制标题
早发性血管紧张素转换酶抑制对心肌毛细血管的影响。
作者：
Thomas Unger;T. Mattfeldt;V. Lamberty;Peter Bock;G. Mall;W. Linz;B. Scholkens;P. Gohlke
观察长期应用血管紧张素转换酶抑制剂雷米普利对自发性高血压大鼠心肌肥厚和毛细血管长度密度的影响。大鼠在子宫中接受高剂量(每天1毫克/公斤)或低剂量(每天0.01毫克/公斤)雷米普利治疗，直到20周龄。给予高剂量雷米普利的动物血压保持正常，而给予低剂量雷米普利的动物与服用赋形剂的对照组同时发生高血压。治疗结束时，各剂量组大鼠心脏组织转换酶活性均受到抑制，呈剂量依赖性。两组均显示心肌毛细血管长度密度增加，同时心肌糖原增加，柠檬酸浓度降低。只有在高剂量治疗的动物中，左心室质量才会减少--而在低剂量治疗的动物中，左心室质量没有减少。我们的结果表明，早期用转换酶抑制剂治疗可以诱导心肌毛细血管增殖，即使剂量太低也不能对抗高血压或左室肥厚的发展。我们推测，激动素的增强可能通过增加心肌血流量来产生这种效应，这是众所周知的心脏血管生成的触发机制。
We investigated the preventive effects of long-term treatment with the angiotensin converting enzyme inhibitor ramipril on myocardial left ventricular hypertrophy and capillary length density in spontaneously hypertensive rats. Rats were treated in utero and subsequently up to 20 weeks of age with a high dose (1 mg/kg per day) or with a low dose (0.01 mg/kg per day) of ramipril. Animals given a high dose of ramipril remained normotensive, whereas those given a low dose developed hypertension in parallel to vehicle-treated controls. At the end of the treatment period, converting enzyme activity in heart tissue was inhibited dose-dependently in the treated groups. Both groups revealed an increase in myocardial capillary length density together with increased myocardial glycogen and reduced citric acid concentrations. Left ventricular mass was reduced only in high dose- but not in low dose-treated animals. Our results demonstrate that early onset treatment with a converting enzyme inhibitor can induce myocardial capillary proliferation, even at doses too low to antagonize the development of hypertension or left ventricular hypertrophy. We hypothesize that potentiation of kinins is responsible for this effect, probably by augmenting myocardial blood flow, which is a well-known trigger mechanism of angiogenesis in the heart.
影响因子：
8.3
作者：
BERK, BC;VEKSHTEIN, V;TSUDA, T
通讯作者：
TSUDA, T
影响因子：
8.3
作者：
MARBAN, E;KORETSUNE, Y
通讯作者：
KORETSUNE, Y
压力超负荷肥厚的心肌特征。
DOI：
--
发表时间：
1984
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Breisch,EA;White,FC;Bloor,CM
通讯作者：
Bloor,CM