Dysregulation of calcium homeostasis after severe burn injury in children: Possible role of magnesium depletion
Dysregulation of calcium homeostasis after severe burn injury in children: Possible role of magnesium depletion
复制标题
DOI：
10.1016/s0022-3476(97)70161-6
复制
发表时间：
1997-08-01
影响因子：
5.1
通讯作者：
Herndon, DN
中科院分区：
文献类型：
--
作者：
Klein, GL;Nicolai, M;Herndon, DN
Objective: To determine the cause and extent of hypocalcemia observed in childDesign: We studied 10 children with burns covering 57% +/- 17% (SD) body surface area, ages 9.6 +/- 4.7 years, who were admitted consecutively during a 6-month period. Diet supplied a minimum of 2.7 gm/m(2) of calcium, 0.3 gm/m(2) of magnesium, and 2.2 gm/m(2) phosphate. Blood specimens were obtained daily for 10 +/- 5 days for the following tests: (1) simultaneous analysis for ionized calcium, magnesium, and intact parathyroid hormone (group A); (2) two of these children, randomly selected, had serial 2-hour determinations on a single day (group B); (3) a modified Ellsworth-Howard test., consisting of a 10-minute infusion of synthetic parathyroid hormone 18 +/- 10 days postburn and associated changes in urinary cyclic adenosine monophosphate excretion and renal threshold phosphate concentration (group C). Three of these children, when nor-momagnesemic, also received a standard magnesium infusion to determine magnesium retention (group D). Data were analyzed with chi-square, regression analysis, and nonparametric testing as appropriate.Results: All patients showed sustained hypocalcemia and hypomagnesemia; intact parathyroid hormone response was inappropriately low and response to synthetic parathyroid hormone infusion was blunted. Lowest ionized calcium levels were associated with hypomagnesemia.Conclusion: Hypoparathyroidism and blunted renal response to parathyroid hormone suggest that magnesium depletion may contribute to their pathogenesis. Magnesium repletion and monitoring are recommended.
